PMID: 11924731Apr 2, 2002Paper

Perindopril reverses myocyte remodeling in the hypertensive heart

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Tatsuyuki OnoderaSeibu Mochizuki

Abstract

Studies have shown that the renin-angiotensin system (RAS) plays an important role in cardiac remodeling induced by hypertension. However, the role of this system on myocyte remodeling remains unclear. In the present study, we have assessed the effect of perindopril, an angiotensin converting enzyme (ACE) inhibitor, in spontaneously hypertensive rats (SHRs) as a means to evaluate the role of RAS in myocyte remodeling. We also investigated the effect of beta blockade on myocyte remodeling. We used female SHRs at 12 weeks of age. They were divided into four experimental groups: a control group, group C; low dose perindopril group (0.3 mg/kg/day, p.o.), group PL; high dose perindopril group (3 mg/kg/day, p.o.), group PH; and bisoprolol group (60 mg/kg/day, p.o.), group B. We isolated myocytes from these rats after 4 weeks. LV myocyte volume and cross-sectional area decreased in groups PL and PH compared to group C. LV myocyte length decreased in group PH compared to group C. However, there was no morphological change in LV myocytes in group B compared to group C. In summary, ACE inhibitors reversed cardiac hypertrophy mainly by a reduction in LV myocyte volume; however, beta blockade did not reverse myocyte remodeling. These resul...Continue Reading

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Citations

Jan 31, 2016·Medical Hypotheses·Begoña Quintana-Villamandos, Emilio Delgado-Baeza
Dec 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rumiko KurosakiTsutomu Araki
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nan JiaAkira Kitabatake
Mar 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hongzhuan ShengJinan Zhang
Oct 22, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shingo SekiSeibu Mochizuki
Jul 30, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wen Qiang ChenYun Zhang
Oct 16, 2012·Journal of Cardiovascular Pharmacology·Can ChenZhi-Gen Li

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