Perindopril/amlodipine (Prestalia(®)): a review in hypertension

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Matt Shirley, Paul L McCormack

Abstract

Perindopril, an ACE inhibitor, and amlodipine, a dihydropyridine calcium channel blocker, are established antihypertensive agents with complementary mechanisms of action. Recently, a once-daily, orally-administered, fixed-dose combination (FDC) of perindopril arginine plus amlodipine besylate (Prestalia(®); hereafter referred to as perindopril/amlodipine FDC) was approved in the USA for the treatment of hypertension. This article reviews the efficacy and tolerability of perindopril/amlodipine FDC and briefly summarizes the agent's pharmacologic properties. As demonstrated in short-term randomized controlled trials, perindopril/amlodipine FDC was significantly more effective in reducing blood pressure (BP) than monotherapy with either of the component drugs, and it appeared to be more effective than an up-titration scheme using valsartan and valsartan/amlodipine. The FDC agent was generally well tolerated, with the most common adverse events (peripheral edema, cough, headache, and dizziness) being consistent with the well-defined tolerability profiles of the individual component drugs. Furthermore, perindopril/amlodipine FDC was associated with a numerically lower incidence of peripheral edema compared with amlodipine monotherap...Continue Reading

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Citations

Sep 13, 2017·Chemistry : a European Journal·Rajdip Roy, Parthasarathi Dastidar
Nov 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristyna KrasulovaPavel Anzenbacher

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