Perineural Invasion in Squamous Cell Carcinoma of the Oral Cavity: Histology, Tumor Stage, and Outcome

Laryngoscope Investigative Otolaryngology
Roman D LaskeGerhard F Huber

Abstract

To analyze the impact of different types of perineural invasion (PNI) in squamous cell carcinoma (SCC) of the oral cavity on overall survival and recurrence rate, with a special focus on histologic subtypes and tumor stage. Retrospective case-control study with clinicopathological analysis. Seventeen patients who received primary surgical treatment for SCC of the oral cavity with PNI were matched to a control group. In a histologic review, PNI was classified into subtypes according to an adapted Liebig classification. The term type A was used to describe tumor invasion into the nerve, whereas type B was used to describe circumferential growth around the nerve. Clinical charts were reviewed, and a Kaplan-Meier survival analysis was performed. The recurrence-free survival rates were 47.1% versus 80.4% (PNI vs. matched control group, P < 0.05), 60.0% versus 94.1% (PNI in stage I and II disease vs. matched control group, P < 0.05) and 41.7% versus 73.5% (PNI in stage III and IV disease vs. matched control group, P < 0.05). In most cases (n = 9) of PNI, both histologic subtypes (type A and type B) were present. Five cases exclusively showed type A, and three cases exclusively showed type B. Perineural invasion in early disease oral ...Continue Reading

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Citations

Dec 28, 2016·Case Reports in Dentistry·Gopinath Thilak Parepady SundarSourabh M Gohil
Jul 10, 2019·Imaging Science in Dentistry·Hamed MortazaviFatemeh Safari
Jan 27, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Yan LiMin Yao
Oct 4, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Shadi AlzahraniBrent B Ward

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