Abstract
Esophageal squamous cell carcinoma (ESCC) at pN0M0 can be more locally aggressive and disseminated than those with lymph node and distant metastasis. Perineural invasion (PNI) is reported as a poor prognostic factor in cancer and is thought to be related to regional tumor spread and metastasis. However, its clinicopathological role and meaning for treatment in pN0M0 ESCC are unknown. We applied scoring methods of PNI and lymphatic and vascular invasion (LI, VI) based on immunohistochemistry staining on tumor tissues of pN0M0 ESCC patients. ROC analyses, Kaplan-Meier analyses, Cox regression, and χ2 test were performed for survival analysis, comparison of PNI with LI and VI, and exploration of the relevance between PNI and other clinicopathological features. Presence of PNI was significantly associated with poor survival in pN0M0 patients, whereas LI and VI were not predictive of outcome (P > 0.05). Neural invasion index (NII), defined as the ratio of the number of tumor-invaded nerves to the total number of nerves per tumor microsection, was the most consistent measure of PNI (P = 0.006, HR = 6.892, 1.731-27.428). Postoperative radiotherapy significantly improved survival in high-NII patients (P = 0.035, HR = 0.390, 0.163-0.936...Continue Reading
References
Oct 27, 2004·The British Journal of Surgery·O A KhanF D Beggs
Jun 2, 2009·Cancer·Catherine LiebigDaniel Albo
Jan 20, 2010·Archives of Surgery·Clarisse EvenoMarc Pocard
Mar 10, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C L DonohoeJ V Reynolds
Nov 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Florian LieblGüralp O Ceyhan
Jun 3, 2014·BMC Cancer·Jie-Wei ChenMu-Yan Cai
Nov 8, 2014·Annals of Surgery·Florian LieblGüralp O Ceyhan
Nov 30, 2014·Medical Oncology·Xiao-Ling XuWei-Min Mao
Nov 12, 2015·British Journal of Cancer·S M LagardeS M Griffin
May 7, 2016·Nature Reviews. Cancer·Moran AmitZiv Gil
Dec 20, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Andrea P MoyStefan Kraft
Jan 17, 2017·Oncogene·M AmitZ Gil
Mar 4, 2017·Scientific Reports·Guanghui XuHongwei Zhang
Mar 16, 2017·Cancer Cell·Benoni BoillyHubert Hondermarck
May 31, 2017·Pathology, Research and Practice·Hui WangYuqing Ma
Aug 22, 2017·Gastroenterology·Christian C AbnetWen-Qiang Wei
Feb 6, 2018·Lancet·Claudia AllemaniUNKNOWN CONCORD Working Group
Apr 17, 2018·Histopathology·Viktor H KoelzerKirsten D Mertz
Sep 2, 2018·Oncogene·Shorook Na'araZiv Gil
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Feb 2, 2019·Head & Neck·Ollivier LaccourreyeQuentin Lisan
Jul 17, 2019·Nature Medicine·Gabriele CampanellaThomas J Fuchs
Jul 19, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Jaffer A AjaniLenora A Pluchino
Citations
Jul 8, 2020·Annals of Surgical Oncology·Yuan-Ning Guo, Min Su
Jul 22, 2020·Annals of Surgical Oncology·Andrew M Popoff
Apr 4, 2021·Thoracic Cancer·Ha Eun KimSun Ill Kim