Abstract
Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1). There is a large body of evidence supporting a role for TRPV1 in noxious-mediated and inflammatory hyperalgesic responses. In this study, we evaluated low, graded, doses of perineural RTX as a method for regional pain control. We hypothesized that this approach can provide long-term, but reversible, blockade of a portion of nociceptive afferent fibers within peripheral nerves when given at a site remote from the neuronal perikarya in the dorsal root ganglia. Following perineural RTX application to the sciatic nerve, we demonstrated a significant inhibition of inflammatory nociception that was dose- and time-dependent. At the same time, treated animals maintained normal proprioceptive sensations and motor control, and other nociceptive responses were largely unaffected. Using a range of mechanical and thermal algesic tests, we found that the most sensitive measure following perineural RTX administration was inhibition of inflammatory hyperalgesia. Recovery studies showed that physiologic sensory function could return as early as two weeks post-RTX treatment, however, immunohistoch...Continue Reading
References
Oct 1, 1979·Pain·P D WallM M Tomkiewicz
Jan 1, 1992·Life Sciences·A Dray
Jan 1, 1990·Neuroscience·G Jancsó, S N Lawson
Jul 12, 1988·Brain Research·M J IadarolaJ R Naranjo
Jan 1, 1988·Pain·K HargreavesJ Joris
May 1, 1987·Anesthesia and Analgesia·K S MaysM Schnapp
Mar 11, 1985·Brain Research·J M ChungW D Willis
Jan 1, 1982·Neuroscience·M Fitzgerald, C J Woolf
Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·G JancśoA Jancsó-Gábor
Aug 2, 1996·Journal of Medicinal Chemistry·G AppendinoA Szallasi
Mar 28, 1997·Brain Research·X J XuA Szallasi
Dec 31, 1997·Nature·M J CaterinaD Julius
Oct 13, 1999·Brain Research·T SzaboP M Blumberg
Apr 15, 2000·Science·M J CaterinaD Julius
May 23, 2000·Nature·J B DavisS A Sheardown
Jan 2, 2001·The Journal of Biological Chemistry·Z OlahM J Iadarola
Feb 28, 2002·Molecular Cell·Craig MontellMichael X Zhu
Apr 5, 2002·Trends in Pharmacological Sciences·Martin J GunthorpeJohn B Davis
Apr 26, 2002·Anesthesia and Analgesia·Igor KissinEdwin L Bradley
Jan 1, 1990·The European Journal of Neuroscience·Adrian PiniBruce Lynn
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·James D PomonisKatharine Walker
Jul 12, 2003·Pain·John K NeubertMichael J Iadarola
Nov 26, 2003·Neurotoxicology·Robert M CaudleZoltan Olah
May 5, 2004·The Journal of Clinical Investigation·Laszlo KaraiMichael J Iadarola
Dec 24, 2004·The Journal of Pharmacology and Experimental Therapeutics·Narender R GavvaJames J S Treanor
Feb 25, 2005·Anesthesia and Analgesia·Igor KissinEdwin L Bradley
Jun 14, 2005·Neuroscience Letters·Angelika VargaZsuzsanna Helyes
Oct 26, 2005·Neuroscience Letters·Luis MenéndezAna Baamonde
Oct 27, 2005·Anesthesiology·Dorothy Cimino BrownAndrew J Mannes
Sep 26, 2006·Trends in Molecular Medicine·Arpad SzallasiPierangelo Geppetti
Feb 27, 2007·Biochimica Et Biophysica Acta·Jon D Levine, Nicole Alessandri-Haber
May 1, 2007·Biochimica Et Biophysica Acta·Daniel N CortrightDaniel C Broom
Citations
Dec 5, 2012·PloS One·Yu-Lin HsiehSung-Tsang Hsieh
Nov 10, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ramy E AbdelhamidAlice A Larson
Apr 22, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·László PeczeZoltán Oláh
Sep 25, 2012·Molecular Pain·Evan E LebovitzMichael J Iadarola
Aug 3, 2013·The Kaohsiung Journal of Medical Sciences·Tin-Hsin HsiaoYu-Lin Hsieh
Jun 18, 2011·The Journal of Pain : Official Journal of the American Pain Society·Mahendra BishnoiLouis S Premkumar
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Simon N CollinsKaspar Matiasek
Jul 24, 2010·The Spine Journal : Official Journal of the North American Spine Society·Beth A Winkelstein, Jeffrey V Kras
Oct 7, 2009·Neuroscience·J H JangJ W Leem
Mar 17, 2010·Pain Practice : the Official Journal of World Institute of Pain·Mark A Schumacher
Mar 19, 2013·European Journal of Pharmacology·Jill-Desiree BredersonArpad Szallasi
Oct 3, 2008·Molecular Pain·John K NeubertRobert M Caudle
May 6, 2014·Pain·Ivica MatakZdravko Lacković
Oct 31, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Margaux M SalasDayna L Averitt
Nov 4, 2016·Pharmaceuticals·Man-Kyo Chung, James N Campbell
Oct 13, 2010·Molecular Pain·Enza PalazzoSabatino Maione
Sep 24, 2008·Bioorganic & Medicinal Chemistry·Eun Joo RohKenneth A Jacobson
Feb 7, 2018·The Journal of Clinical Investigation·Matthew R SapioMichael J Iadarola
Aug 28, 2014·The Journal of Trauma and Acute Care Surgery·John L CliffordDayna R Loyd
Feb 18, 2020·The Journal of Comparative Neurology·Hayate JavedSafa Shehab
Sep 26, 2019·Frontiers in Pharmacology·Paramita BasuDayna L Averitt
Dec 23, 2017·Anesthesiology·Stephen J RaithelAndrew J Mannes
Jul 18, 2018·Pain·Michael J IadarolaDorothy Cimino Brown
Jan 12, 2021·Frontiers in Neuroscience·Matthew R SapioMichael J Iadarola
Nov 13, 2020·Pharmacology & Therapeutics·Vipin AroraMan-Kyo Chung
May 1, 2021·Animals : an Open Access Journal From MDPI·Alison SmallIan Colditz
Aug 24, 2021·Frontiers in Pharmacology·Michael J IadarolaAndrew J Mannes
Jun 19, 2009·Anesthesia and Analgesia·Susan M KramerEric Longstaff
Nov 26, 2009·Anesthesia and Analgesia·Jin-Woo ShinPeter Gerner