Perineural steroids for trauma and compression-related peripheral neuropathic pain: a systematic review and meta-analysis

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Anuj BhatiaPrakesh S Shah

Abstract

Perineural steroids are often used to treat chronic peripheral neuropathic pain (NP) secondary to trauma or compression. Nevertheless, when compared with local anesthetics (LA) or conventional medical management (CMM), their efficacy and safety in patients with trauma or compression-related neuropathic pain syndromes is unclear. The purpose of this systematic review and meta-analysis was to determine the efficacy and safety of perineural steroids in compression or trauma-related NP after one to three months of injection. We reviewed randomized controlled trials from MEDLINE(®), EMBASE™, Cochrane central register of controlled trials, Cochrane database of systematic reviews, and Google Scholar (first 200 hits) up to April 2014 that compared perineural injections of steroids with LA or CMM in adult patients with trauma or compression-related chronic peripheral NP. A meta-analysis was performed on the data on pain scores measured at one to three months after the interventions. Quality of evidence was classified using the GRADE system. Two authors independently reviewed all identified titles and abstracts for eligibility. Five trials comprising 353 patients (177 in the steroid group and 176 in the comparator groups) were included. ...Continue Reading

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Citations

Apr 2, 2016·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J S KhanA Bhatia
Feb 17, 2017·Nature Reviews. Disease Primers·Luana CollocaSrinivasa N Raja

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