Perineurioma: a clinicopathological study of eight cases

Pathology
Andrew J RankineDominic V Spagnolo

Abstract

Perineuriomas (PN) are uncommon, benign neoplasms that mimic a number of benign and malignant soft tissue lesions. There are two main forms: a rare intraneural PN (IPN), and a relatively more common extraneural soft tissue PN (STPN) including a conventional form (STPNc), sclerosing (SPN), reticular and lipomatous variants. Their diagnosis requires immunohistochemical (IHC) and/or ultrastructural (US) confirmation of perineurial cell differentiation. This study aims to review the clinicopathological features of eight PN we encountered recently, to raise awareness of PN as an entity and to highlight the differential diagnoses which include potentially aggressive lesions. Clinical, histological, IHC and US features of seven STPN and one IPN were studied. The eight PN arose in the limbs of six females and two males aged 30-58 years. Five STPN occurred in subcutis, one intramuscularly and one intradermally. The STPN were well-circumscribed, multinodular growths. STPNc contained bland spindle cells with long cytoplasmic processes arranged in lamellae, storiform patterns and whorls. Three SPN were acrally located and additionally contained small epithelioid cells in cords and clusters in a myxohyaline stroma with extensive sclerosis. ...Continue Reading

Citations

Aug 26, 2006·Nature Reviews. Immunology·Alistair J CochranRichard Essner
Jul 2, 2009·Brain : a Journal of Neurology·Michelle L MauermannP James B Dyck
Aug 13, 2005·The American Journal of Surgical Pathology·Jane E BrockSara O Vargas
Nov 24, 2006·The American Journal of Surgical Pathology·Clovis W PitchfordJustin M M Cates
Jun 7, 2012·The American Journal of Dermatopathology·Francisco IzquierdoEmiliano Honrado
Jul 23, 2009·The American Journal of Surgical Pathology·Jason L HornickChristopher D M Fletcher
Feb 15, 2013·Ophthalmic Plastic and Reconstructive Surgery·Amanda B SalterYoash R Enzer
Sep 1, 2011·Surgical Pathology Clinics·Ashley M Cimino-Mathews
Apr 27, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Wilfredo Alejandro González-ArriagadaMarcio Ajudarte Lopes
Dec 17, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rebeca Souza AzevedoFábio Ramôa Pires
Feb 16, 2008·Human Pathology·Joseph D Jakowski, Paul E Wakely
Apr 24, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Maria SiponenHannu Tuominen
May 2, 2007·Muscle & Nerve·Doris NguyenJasper R Daube
Dec 31, 2016·Journal of Cutaneous Pathology·Ricardo S Macarenco, Jade Cury-Martins
Aug 10, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kati P PummiSirkku A Peltonen
Oct 17, 2006·International Journal of Surgical Pathology·Dmitry V KazakovMichal Michal
May 20, 2018·Clinical and Experimental Dermatology·B BhoyrulG I Stables
Sep 30, 2008·Journal of Clinical Pathology·S A HaiderT A McCulloch
Apr 20, 2013·The American Journal of Surgical Pathology·Luis RequenaHeinz Kutzner
Jun 17, 2005·The American Journal of Surgical Pathology·Jason L Hornick, Christopher D M Fletcher
Mar 2, 2010·Anais Brasileiros De Dermatologia·Thiago Jeunon de Sousa VargasGeoffrey J Golttlieb
Dec 4, 2020·World Journal of Clinical Cases·Hai-Ying ZhouHui Lu
Sep 11, 2007·Archives of Pathology & Laboratory Medicine·Bobby L BoyantonMeenakshi B Bhattacharjee
Jun 3, 2006·Archives of Pathology & Laboratory Medicine·Antonio D'AntonioVito Ninfo

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