Perineuronal nets in the rat medial nucleus of the trapezoid body surround neurons immunoreactive for various amino acids, calcium-binding proteins and the potassium channel subunit Kv3.1b

Brain Research
W HärtigGert Brückner

Abstract

Perineuronal nets (PNs) are known as chondroitin sulfate-rich, lattice-like coatings of the extracellular matrix ensheathing mainly GABAergic, parvalbumin-containing neurons especially in the cerebral cortex. PNs have also been detected around GABA-immunonegative cells which were shown to be not aminergic, cholinergic, nitrinergic or peptidergic in various brain regions of some mammalian species. To find out whether glycine and aspartate may occur in net-bearing neurons the present study was focused on the rat medial nucleus of the trapezoid body (MNTB) which contains a large portion of cells immunoreactive for these amino acids, but appears to be devoid of GABA-immunoreactive cell bodies. PNs were detected around many glycine- and aspartate-immunopositive neurons in the MNTB by carbocyanine double labeling and confocal laser scanning microscopy. An additional finding was that the lectin-cytochemically stained extracellular matrix surrounds the calretinin-immunoreactive calyces of Held known as giant glutamatergic endbulbs which cover glycinergic principal cells in the MNTB. As elucidated by triple fluorescence labeling, the vast majority of somata co-expressed the calcium-binding proteins parvalbumin and calbindin, but not cal...Continue Reading

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Citations

Mar 23, 2012·Cell and Tissue Research·Difei Wang, James Fawcett
May 18, 2013·Brain Structure & Function·Eva RáczClara Matesz
Aug 22, 2008·Journal of Neuropathology and Experimental Neurology·Elizabeth GraySeth Love
May 28, 2015·Developmental Neurobiology·Douglas R KolsonGeorge A Spirou
Sep 22, 2010·Journal of Neuroscience Research·Georgina GátiAlán Alpár
Sep 8, 2011·Developmental Neurobiology·Jessica C F KwokJames W Fawcett
May 26, 2010·The European Journal of Neuroscience·Eckart D GundelfingerMartin Heine
Apr 12, 2016·Frontiers in Physiology·Brian L Jones, Stephen M Smith
Apr 16, 2015·Frontiers in Neuroanatomy·Randy J Kulesza, Benedikt Grothe
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Nov 19, 2014·Molecular Neurobiology·Anne SuttkusThomas Arendt
Jul 3, 2009·Journal of Neurophysiology·Ivan MilenkovicRudolf Rübsamen
Feb 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elizabeth A McCullaghYuan Wang
May 10, 2018·Frontiers in Cellular Neuroscience·Przemysław KurowskiPaweł Szulczyk
Feb 7, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Weiping SuLarry S Sherman
Jul 21, 2004·Neurobiology of Disease·Rafael Medina-FloresClayton A Wiley

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