Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala

Brain Structure & Function
Alexander J McDonaldColin J Barnstable

Abstract

Perineuronal nets (PNNs) are specialized condensations of extracellular matrix that ensheath particular neuronal subpopulations in the brain and spinal cord. PNNs regulate synaptic plasticity, including the encoding of fear memories by the amygdala. The present immunohistochemical investigation studied PNN structure and distribution, as well as the neurochemistry of their ensheathed neurons, in the rat amygdala using monoclonal antibody VC1.1, which recognizes a glucuronic acid 3-sulfate glycan associated with PNNs in the cerebral cortex. VC1.1+ PNNs surrounded the cell bodies and dendrites of a subset of nonpyramidal neurons in cortex-like portions of the amygdala (basolateral amygdalar complex, cortical nuclei, nucleus of the lateral olfactory tract, and amygdalohippocampal region). There was also significant neuropilar VC1.1 immunoreactivity, whose density varied in different amygdalar nuclei. Cell counts in the basolateral nucleus revealed that virtually all neurons ensheathed by VC1.1+ PNNs were parvalbumin-positive (PV+) interneurons, and these VC1.1+/PV+ cells constituted 60% of all PV+ interneurons, including all of the larger PV+ neurons. Approximately 70% of VC1.1+ neurons were calbindin-positive (CB+), and these VC1....Continue Reading

References

Jan 1, 1992·Progress in Brain Research·C J BarnstableY Arimatsu
Dec 10, 1982·The Journal of Comparative Neurology·A J McDonald
Dec 1, 1981·The American Journal of Anatomy·A J McDonald, J L Culberson
Jan 1, 1994·Brain Research. Brain Research Reviews·M R Celio, I Blümcke
Jun 30, 1997·The Journal of Comparative Neurology·A J McDonald
Jan 9, 1999·Trends in Neurosciences·M R CelioL Vitellaro-Zuccarello
Nov 15, 2000·The Journal of Comparative Neurology·G BrücknerM Schachner
Jun 5, 2003·Nature Reviews. Neuroscience·Alexander Dityatev, Melitta Schachner
Sep 15, 2005·Hippocampus·Hans-Christian PapeThomas Seidenbecher
Nov 2, 2005·Nature Reviews. Neuroscience·Takao K Hensch
Dec 24, 2005·The Journal of Comparative Neurology·Daniela CarulliJames W Fawcett
Apr 15, 2006·The Journal of Comparative Neurology·Harry PantazopoulosSabina Berretta
Jul 21, 2006·The Journal of Comparative Neurology·Donald Gordon RainnieAlexander Joseph McDonald
Sep 12, 2006·Trends in Molecular Medicine·Mariano S Viapiano, Russell T Matthews
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alan R Woodruff, Pankaj Sah
Nov 7, 2008·Biological Psychiatry·Daphne J HoltDonald C Goff
Sep 5, 2009·Science·Nadine GogollaCyril Herry
Aug 23, 2011·Neuropharmacology·Sabina Berretta
Mar 23, 2012·Cell and Tissue Research·Difei Wang, James Fawcett
Jun 7, 2012·Cellular and Molecular Life Sciences : CMLS·Yasuhiko Kizuka, Shogo Oka
Jul 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Roger Y Tsien

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Citations

Jan 1, 2018·Claustrum·Mihovil Pletikos, Kathleen S Rockland

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