Perinuclear leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) as prognostic indicators in astrocytic tumors

Acta Neuropathologica
Dongsheng GuoRoger Henriksson

Abstract

We have previously characterized three human leucine-rich repeats and immunoglobulin-like domains (LRIG) genes and proteins, named LRIG1-3 and proposed that they may act as suppressors of tumor growth. The LRIG1 transmembrane protein antagonizes the activity of epidermal growth factor receptor family receptor tyrosine kinases. In this study, we evaluated the mRNA expression level of LRIG1-3 in human glioma cell lines and control-matched glioma tissues, characterized the sub-cellular localization of an LRIG3-GFP fusion protein, and analyzed the relationship between sub-cellular localization of LRIG1-3 and clinical parameters in 404 astrocytic tumors by immunohistochemistry. LRIG1-3 mRNA was detected in all human glioma cell lines and matched glioma samples, with large differences in the expression levels. Ectopically expressed LRIG3-GFP localized to perinuclear and cytoplasmic compartments, and to the cell surface of transfected glioma cells. Perinuclear staining of LRIG1-3 was associated with low WHO grade and better survival of the patients. Perinuclear staining of LRIG3 was associated with a lower proliferation index and was in addition to tumor grade, an independent prognostic factor. Furthermore, within the groups of grade ...Continue Reading

References

Sep 1, 1989·The British Journal of Dermatology·N MatsuyoshiS Imamura
Jun 1, 1989·The Journal of Dermatology·N DosakaS Imamura
Dec 31, 1997·The Journal of Clinical Investigation·P W CookM R Pittelkow
Sep 17, 1999·The American Journal of Pathology·S KnuutilaY Zhu
Jun 21, 2001·Biochemical and Biophysical Research Communications·J NilssonH Hedman
Jun 18, 2002·FEBS Letters·Yutaka SuzukiSatoshi Itami
Sep 18, 2002·Acta Oncologica·Håkan HedmanRoger Henriksson
Apr 10, 2003·Cell and Tissue Research·Jonas NilssonHåkan Hedman
Apr 18, 2003·Oncogene·Paul S MischelStanley F Nelson
May 15, 2003·Brain Pathology·Hannu HaapasaloYlermi Soini
Jul 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang W A SchamelMichael Reth
Mar 30, 2004·Journal of Surgical Oncology·Mirta VarelaMaría Guadalupe Pallotta
May 18, 2004·Gene·Camilla HolmlundHåkan Hedman
May 19, 2004·Acta Neuropathologica·Ulrika AnderssonRoger Henriksson
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Eve PaquetDavid B Williams
Jun 29, 2004·Journal of Neuro-oncology·Stella M RanuncoloLydia Puricelli
Sep 4, 2004·The Journal of Biological Chemistry·Melanie B LaederichColleen Sweeney
Jan 28, 2005·Journal of Neuro-oncology·Koichi IchimuraV Peter Collins

❮ Previous
Next ❯

Citations

Mar 30, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Dongsheng GuoTing Lei
Feb 19, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Mingjun CaiTing Lei
Apr 21, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaoyi YuanZhangqun Ye
Aug 9, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Huaqiu ZhangDongsheng Guo
Nov 1, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hongkuan YangTing Lei
Nov 11, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Camilla HolmlundHåkan Hedman
May 3, 2013·The Journal of Clinical Investigation·Natividad PozoPilar Sánchez-Gómez
Sep 4, 2014·Endocrine-related Cancer·Catalina SimionColleen Sweeney
Mar 31, 2015·Acta Oncologica·Samuel KvarnbrinkHåkan Hedman
Sep 3, 2014·Acta Oncologica·David LindquistHåkan Hedman
Feb 25, 2015·Journal of the Neurological Sciences·Dongsheng GuoTing Lei
Nov 27, 2007·The Journal of Investigative Dermatology·Terese KarlssonHåkan Hedman
Oct 14, 2008·Gene Expression Patterns : GEP·Shunsaku HommaHiroyuki Yaginuma
Jan 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Håkan Hedman, Roger Henriksson
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Silvia Goldoni, Renato V Iozzo
Jan 23, 2013·International Journal of Oncology·Feng MaoXiaoping Chen
Mar 25, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martin HellströmHåkan Hedman
Aug 16, 2017·Experimental and Therapeutic Medicine·Long ChenYouxin Zhou
Oct 5, 2016·Experimental and Therapeutic Medicine·Xiaofang Jiang, Huiwu Li
Jul 12, 2014·Oncology Letters·Guangchuan WangHuijuan Song
Feb 14, 2018·International Journal of Oncology·David LindquistHåkan Hedman
Jan 20, 2021·BMC Medical Genomics·Maryam BakheradTayebeh Majidizadeh
Jan 6, 2021·Amino Acids·Ernest Jan BobeffDariusz Jan Jaskólski
Jan 22, 2021·Seminars in Cancer Biology·Yibing JiDean G Tang
Nov 30, 2021·Journal of Immunoassay & Immunochemistry·Marwa M Serag El-DienNanis Shawky Holah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Håkan Hedman, R Henriksson
Neuropathology : Official Journal of the Japanese Society of Neuropathology
Camilla HolmlundH Hedman
Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Dongsheng GuoTing Lei
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Atsushi TanemuraSatoshi Itami
© 2021 Meta ULC. All rights reserved