Periocular carboplatin for retinoblastoma: long-term report (12 years) on efficacy and toxicity

The British Journal of Ophthalmology
Brian P MarrDavid H Abramson

Abstract

To report the experience of the authors with efficacy and toxicity of periocular chemotherapy over a 12-year period. 102 periocular injections of 2 cc (10 mg of carboplatin/1 cc) were given every 4-6 weeks in 33 eyes of 29 patients. Patient's data were reviewed retrospectively. Thirty-three eyes were followed for 7-148 months following initiation of periocular injections, and 13 (39%) have avoided enucleation. There were two cases of second malignancy resulting in one death and one survivor, two survivors of metastatic disease, and two survivors of orbital recurrence. Twenty eyes were enucleated for disease progression at a mean time of 15 months postinitiation of periocular carboplatin (POC). The Kaplan-Meier estimate of eye survival at 36 months is 36%. Eleven of the 13 salvaged eyes received concurrent treatment with chemotherapy (n=4, 30%), external beam radiation and chemotherapy in (n=6, 46%), or brachytherapy (n=1, 8%). Two of the salvaged eyes (16%) were treated with POC alone. Orbital swelling occurred in 14/33 (42%) eyes. There were no symptomatic motility disorders. One severe toxicity reaction resulted in acute loss of vision, down to light perception, which failed to recover and one eye had progression of optic ner...Continue Reading

Citations

Jan 16, 2014·Annual Review of Medicine·David H Abramson
Sep 5, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kai B KangDavid H Abramson
Feb 23, 2013·Expert Opinion on Drug Discovery·Samuel K HoustonTimothy G Murray
Dec 10, 2013·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Yacoub A YousefHelen Dimaras
Dec 7, 2013·Journal of Pediatric Ophthalmology and Strabismus·Theodora HadjistilianouDomenico Mastrangelo
Nov 19, 2013·Pediatric Blood & Cancer·Guillermo L ChantadaJulio Manzitti
Apr 2, 2015·Indian Journal of Ophthalmology·Swathi Kaliki, Carol L Shields
Apr 2, 2015·Indian Journal of Ophthalmology·Fairooz P Manjandavida, Carol L Shields
Nov 30, 2016·International Ophthalmology Clinics·Shuai YuanAnthony B Daniels
Sep 13, 2016·Retina·Paula SchaiquevichDavid H Abramson
Nov 1, 2013·Asia-Pacific Journal of Ophthalmology·Fairooz P ManjandavidaJerry A Shields
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Wei QuShaowei Wang

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