Periocular contact dermatitis with use of topical voriconazole 1% in mycotic keratitis

BMJ Case Reports
Pranita SahayJeewan S Titiyal

Abstract

We present two cases of culture-proven fungal keratitis on natamycin treatment which developed periocular erythema, oedema, burning sensation and pruritus within 48 hours of the addition of topical voriconazole. On clinical examination, periocular erythema with induration was noted. A diagnosis of orbital cellulitis was suspected, but the absence of pain and tenderness refuted the diagnosis on clinical grounds. A dermatology consultation was sought, and a diagnosis of periocular contact dermatitis with voriconazole was made. A skin patch test was performed with the same medication; however, it was negative. Topical voriconazole therapy was withdrawn, and the patient was prescribed cold compresses and oral antihistamine medication, to which they responded well.

References

Dec 26, 2006·American Journal of Ophthalmology·Vatinee Y BunyaElisabeth J Cohen
Nov 13, 2008·Antimicrobial Agents and Chemotherapy·Antoine DupuisNicolas Venisse
May 19, 2009·European Journal of Dermatology : EJD·Audrey NosbaumJean-François Nicolas
May 4, 2012·Ophthalmology·Swapnil ParchandArunaloke Chakrabarty
May 28, 2013·JAMA Ophthalmology·N Venkatesh PrajnaUNKNOWN Mycotic Ulcer Treatment Trial Group
Dec 24, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kiyanna WilliamsSarah Tuttleton Arron
Oct 25, 2016·Dermatitis : Contact, Atopic, Occupational, Drug·Katherine R Grey, Erin M Warshaw
Oct 28, 2016·JAMA Ophthalmology·N Venkatesh PrajnaUNKNOWN Mycotic Ulcer Treatment Trial II Group

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Citations

Aug 3, 2020·Current Opinion in Allergy and Clinical Immunology·Nir ErdinestAbraham Solomon

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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