Periocular Melanoma In Situ Treated With Imiquimod

Ophthalmic Plastic and Reconstructive Surgery
Maxwell D EliaFlora Levin

Abstract

To evaluate the efficacy of topical 5% imiquimod cream in the treatment of periocular melanoma in situ (lentigo maligna). Retrospective case series. There were 12 patients in this series, and the mean patient age was 77 years. The anatomical locations were the lower eyelid (n=5), upper and lower eyelid (n=4), lower eyelid including the eyelid margin (n=1), brow (n=1), and the medial canthus (n=1). Topical 5% imiquimod cream was used as a primary treatment (n=6) or as an adjunctive therapy following local excision (n=2), cryotherapy (n=2), or excisional biopsy with cryotherapy (n=2). Twelve patients with periocular melanoma in situ were treated with topical 5% imiquimod cream daily for a mean treatment period of 3.9 months. The clinical features of the patients and the responses to treatment were evaluated in a retrospective case series. Histologic clearance of atypical melanocytes. Eleven patients achieved complete histologic clearance of atypical melanocytes on post-treatment biopsy. One patient could not tolerate local irritation from imiquimod and stopped in the first month of therapy with residual disease. The median follow-up time was 1.5 years. Side effects included redness (n=12), discomfort (n=6), swelling (n=4), ectrop...Continue Reading

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Citations

Apr 12, 2017·Asia-Pacific Journal of Ophthalmology·Nora Silverman, Roman Shinder
Nov 20, 2020·Dermatologic Therapy·Marcos Oro-AyudeAngeles Flórez

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