Periodic leg movements in sleep in elderly patients with Parkinsonism and Alzheimer's disease.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Donald L BliwiseDavid B Rye

Abstract

  Periodic leg movements in sleep (PLMS) are non-epileptiform, repetitive movements of the lower limbs that have been associated with apparent dopamine deficiency. We hypothesized that elderly patients with a disease characterized primarily by dopamine depletion (Parkinsonism) would have higher rates of PLMS than age-matched controls or a different neurodegenerative condition not primarily involving a hypodopaminergic state, Alzheimer's disease (AD).   We compared rates of PLMS derived from in-laboratory overnight polysomnography in patients with Parkinsonism (n = 79), AD (n = 28), and non-neurologically impaired, community-based controls (n = 187).   Patients with Parkinsonism not receiving levodopa had significantly higher rates of PLMS than did patients with Parkinsonism receiving levodopa as well as higher rates than seen in AD and controls. Other medications did not appear to exert the pronounced effect of levodopa on PLMS in this Parkinsonian patient population. The symptom of leg kicking was reported more frequently in Parkinsonism and was associated with higher rates of PLMS. Caregiver reported leg kicking was unrelated to PLMS in AD.  Results are broadly compatible with a dopaminergic hypothesis for PLMS in Parkinsonis...Continue Reading

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Citations

Apr 4, 2015·Journal of Alzheimer's Disease : JAD·Chiara VillaRomina Combi
Jul 31, 2012·Sleep Medicine·Friederike Sixel-DöringClaudia Trenkwalder
May 18, 2016·Current Neurology and Neuroscience Reports·Lynn Marie Trotti, Elias G Karroum
Jan 11, 2019·Behavioral Sciences·Justa Elizabeth González-NaranjoArnoldo Padrón-Sánchez
Jan 18, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Feb 13, 2013·Continuum : Lifelong Learning in Neurology·Nathaniel F Watson, Mari Viola-Saltzman
Jun 11, 2016·Acta Neurologica Scandinavica·A YlikoskiM Partinen
Nov 3, 2016·Current Opinion in Neurology·Panagiotis BargiotasClaudio L Bassetti
Jun 16, 2018·Frontiers in Neuroscience·Anna BrzeckaGjumrakch Aliev
Jun 22, 2013·Current Opinion in Neurology·Maria P GiannoccaroGiuseppe Plazzi
Mar 3, 2020·Neuro-degenerative Diseases·Aylin ReyhaniDerya Karadeniz
Nov 17, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Cheng-Yu TsaiYi-Chun Kuan

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