PMID: 8947306Nov 1, 1996Paper

Periodic naltrexone and propensity to take alcoholic beverage

Alcoholism, Clinical and Experimental Research
L D ReidC L Hubbell

Abstract

For over 2 months, 45 rats were maintained on a daily regimen involving 2 hr a day of access to both water and palatable alcoholic beverage. At first, they took little ethanol. As days progressed, they eventually took over 2 g/kg of ethanol during the 2 hr. Previous research indicates that, without intervention, they would maintain this level of intake indefinitely. All rats were taken off the daily regimen for 30 days and then returned to it, i.e., rats received 30 days of "abstinence". For 35 days following abstinence, one-third of the subjects received placebos daily, one-third received naltrexone (NTX), 10 mg/kg, daily, and the one-third received NTX on days 1-5, 11-15, 21-25, and 31-35 and placebos on the other days. Abstinence reduced all rats' intakes of alcohol compared with pre-abstinence levels. Rats that received only placebos quickly returned to taking alcohol at pre-abstinence levels. Rats that received NTX daily increased their intakes up to the level normally expected for receiving NTX and no abstinence. Because rats receiving daily NTX always drank a fraction of the alcohol consumed by those receiving placebos, NTX's effects did not diminish. As rats sampled alcoholic beverage, however, the effects of abstinence...Continue Reading

References

Nov 1, 1992·Archives of General Psychiatry·J R VolpicelliC P O'Brien
Nov 1, 1992·Archives of General Psychiatry·S S O'MalleyB Rounsaville
Jul 1, 1991·Alcohol·L D ReidC L Hubbell
Jan 1, 1990·Annals of Medicine·J D Sinclair
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Jan 1, 1984·Alcohol·L D Reid, G A Hunter
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Jan 1, 1996·Alcohol·J M Van Ree
Jan 1, 1996·Alcohol·C P O'BrienJ R Volpicelli

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Citations

Jan 1, 1997·Peptides·G A OlsonA J Kastin
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Jorge Juárez, Barrios De Tomasi Eliana
Jan 29, 2011·Annals of the New York Academy of Sciences·John C CrabbeGeorge F Koob
Dec 3, 2009·Alcoholism, Clinical and Experimental Research·Katherine G HillStephen W Kiefer
Jul 6, 2004·Physiology & Behavior·Allen S Levine, Charles J Billington
Mar 9, 2013·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yuya IseTsutomu Suzuki
Mar 19, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Arthur TomieLei Yu
May 29, 2004·Alcoholism, Clinical and Experimental Research·William A BanksJohn E Morley
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allen S LevineCharles J Billington

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