Periodic paralysis

Handbook of Clinical Neurology
Doreen FialhoE Matthews

Abstract

The periodic paralyses are a group of skeletal muscle channelopathies characterizeed by intermittent attacks of muscle weakness often associated with altered serum potassium levels. The underlying genetic defects include mutations in genes encoding the skeletal muscle calcium channel Cav1.1, sodium channel Nav1.4, and potassium channels Kir2.1, Kir3.4, and possibly Kir2.6. Our increasing knowledge of how mutant channels affect muscle excitability has resulted in better understanding of many clinical phenomena which have been known for decades and sheds light on some of the factors that trigger attacks. Insights into the pathophysiology are also leading to new therapeutic approaches.

Citations

Oct 21, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lauren Phillips, Jaya R Trivedi
Nov 15, 2019·Annals of Neurology·Sabrina MetzgerMark M Rich
Oct 16, 2018·Frontiers in Physiology·Virginie Laugel-HaushalterPatimaporn Pungchanchaikul
Nov 17, 2019·Biomolecules·Eva-Maria Zangerl-PlesslMarcel A G van der Heyden
Jun 4, 2020·Continuum : Lifelong Learning in Neurology·Nuri Jacoby
Mar 7, 2020·The Indian Journal of Medical Research·Vishesh VermaAnil S Menon
Jan 5, 2021·European Journal of Applied Physiology·Michael I Lindinger, Simeon P Cairns
Oct 31, 2020·Case Reports in Genetics·Manuela Quiroga-CarrilloFernando Suarez-Obando
Dec 17, 2020·Journal of Neuromuscular Diseases·Jean-François DesaphyBertrand Fontaine
Jul 23, 2021·BMJ Case Reports·Archita MakhariaPradeep Lalwani

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