Periodic Variation of AAK1 in an Aβ1-42 -Induced Mouse Model of Alzheimer's Disease

Journal of Molecular Neuroscience : MN
Xue FuYang Lü

Abstract

Inhibition of endocytosis in an Alzheimer's disease (AD) model has been shown to be able to prevent amyloid β (Aβ)-induced damage and to exert a beneficial effect in treating AD. Adaptor-associated kinase 1 (AAK1), which binds to the adaptor protein complex 2 (AP-2), regulates the process of clathrin-mediated endocytosis. However, how AAK1 expression varies over the course of AD is unknown. In this study, we investigated AAK1 levels in AD model mice over time. Aβ1-42 was used to establish a mouse AD model, and the Morris water maze test was used to characterize the time course of Aβ1-42-induced cognition changes. ELISA was used to determine AAK1 levels in plasma and Aβ1-42 levels in brain tissues. Subsequently, the protein or gene levels of AAK1, AP-2, and Rab5 (an early endosome marker) were tested in each group. The cognitive function of Aβ1-42-induced mice was significantly declined compared to control group, and the deficits reached a peak on day 14, but partly recovered on day 30. Moreover, the level of Aβ1-42 detected with ELISA was highest on day 14, but reduced on day 30, paralleling the cognitive changes in the mice in our study. AAK1, AP-2, and Rab5 expression showed the same periodic variation as the changes in cogni...Continue Reading

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Citations

Mar 14, 2020·BMC Bioinformatics·Ping LuoFang-Xiang Wu
May 12, 2021·Expert Opinion on Therapeutic Patents·Belén Martinez-GualdaSteven De Jonghe

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR

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