Periodically driven force protein translocation through a α-hemolysin biological nano-pore

BioRxiv : the Preprint Server for Biology
Muhammad Adnan Shahzad

Abstract

We study the translocation of protein pulled under the action of time periodically external driving force through α-hemolysin nano-pore using Langevin molecular dynamical simulation. We observe that time depended external pulling force could enhance to more efficient translocation process as compared to protein translocation driven by constant external pulling force. We characterized the time depended force driven translocation mechanism by studying the gain in translocation as a function of frequency. We also present Golestanian plot which shows the modulated evolutions of number of translocation peptides, and of the probability distribution function with frequency as a results of the transmission of force oscillation to translocation dynamics.

Related Concepts

Hemolysin
Peptides
Disease Transmission
Protein Translocation
Simulation
Nuclear Translocation

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