Periodically repeated rituximab administrations in children with refractory nephrotic syndrome: 2-year multicenter observational study

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Toshiyuki TakahashiTadashi Ariga

Abstract

Rituximab (RTX) is effective in maintaining remission in patients with nephrotic syndrome (NS), but a standard protocol of RTX administration has not been established. This study was a 2-year multicenter observational study, in which consistent treatments and evaluations were performed. We enrolled pediatric patients with refractory NS between January 2015 and December 2015. RTX infusion was performed four times at 6-month intervals, followed by mizoribine pulse therapy with early discontinuation of calcineurin inhibitor (CNI). Primary endpoints were the relapse-free survival rate and the number of relapses after RTX administration. Secondary endpoints were changes in side effects associated with long-term steroid administration. Twenty-two patients were analyzed. The relapse-free survival rate at 1 year and 2 years was 50 and 46%, respectively. Twenty-one patients accomplished our protocol and the frequency of relapse was reduced under the discontinuation of CNI. Although two patients were diagnosed with frequent relapse and/or steroid dependency during the observation period, the frequency of relapse decreased with each rituximab dose. Statistically significant improvements in all steroid complications were observed in the fi...Continue Reading

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Citations

May 28, 2019·Frontiers in Pediatrics·Mahmoud KallashJohn D Mahan
Jan 18, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Toshiyuki TakahashiTadashi Ariga
Jun 25, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eugene Yu-Hin Chan, Kjell Tullus
Feb 2, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Beatriz Guzmán MoraisGema Fernández Novo
Sep 22, 2021·Journal of the American Society of Nephrology : JASN·Pietro RavaniGian Marco Ghiggeri
Apr 8, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Toshiyuki TakahashiTadashi Ariga

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