Periodontal changes in liver cirrhosis and post-transplantation patients. II: radiographic findings:

Journal of Periodontology
O Oettinger-BarakM Peled

Abstract

Liver disease and transplantation affect bone turnover. The role of cylosporin A (CsA) in aggravating bone loss is controversial. The aim of the present study was to examine the effect of liver cirrhosis, transplantation, and immunosuppressive therapy with either CsA or tacrolimus on alveolar bone height. The experimental group consisted of 13 liver cirrhosis (LC) patients. A second experimental group included 24 post-liver transplantation patients (PT) receiving CsA or tacrolimus. Seventeen healthy subjects formed a control group. Panoramic x-rays were taken and digitized using a computer-based measurement software to assess alveolar bone height of all available teeth. Bone loss in the PT group (4.57+/-0.56 mm) was significantly higher than the control (C) (2.73+/-0.38 mm); however, it was significantly lower (P = 0.0005) than the LC (6.47+/-0.75 mm). Likewise, alveolar bone loss showed a trend for negative correlation (R = 0.404, P = 0.06) with the duration of immunosuppressive therapy post-liver transplantation. Liver cirrhosis patients demonstrated greater bone loss compared to healthy controls. Restoration of liver functions following transplantation seems to have the potential to reverse some of these radiographic changes...Continue Reading

References

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·I A Katz, S Epstein
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A McDonaldG W McCaughan
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P OrcelM C de Vernejoul
Jun 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J StewartP H Stern
Jan 1, 1982·Immunological Reviews·S Britton, R Palacios
May 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D F RomeroS Epstein
Nov 1, 1994·The American Journal of Medicine·E MeysP D Delmas
Jun 17, 1998·The American Journal of Medicine·M A Rodino, E Shane
Jun 17, 2000·Transplantation Proceedings·S BarakY Baruch
Oct 2, 2001·Journal of Periodontology·O Oettinger-BarakM Peled

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Citations

Jul 31, 2003·Journal of Periodontology·Alejandro A GorustovichMáximo J Giglio
Jan 16, 2016·SAGE Open Medicine·Lea Ladegaard Grønkjær
Jul 14, 2018·Journal of Periodontology·Bruna Di ProfioClaudio Mendes Pannuti

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