Periodontal disease: a potential modifiable risk factor limiting conception

Human Reproduction
Roger HartJohn P Newnham

Abstract

Periodontal disease (PD) is a common chronic infectious and inflammatory disease of the gums and its supporting tissues, associated with several adverse health outcomes including significant obstetric consequences. PD is treatable with good oral hygiene and dental care, and consequently is a modifiable variable that may lead to improvements in adult health. To date, there are no published studies describing the influence of PD on a woman's time to conceive (TTC). This study formed part of the Smile study, which was a multi-centre randomized controlled trial of treatment for PD in mid-pregnancy. PD was defined as the presence of pockets ≥4-mm deep at ≥12 probing sites in fully erupted teeth. At the time of recruitment, women were asked about their TTC and whether they had required fertility treatment. Of 3737 pregnant women recruited to the study, information was available from 3416 spontaneous conceptions, including 1014 cases with PD (29.7%). Planned pregnancies accounted for 1956 of the 3416 pregnancies available for study. For 146 women, the TTC was >12 months and PD was more prevalent in this group (34.9% versus 25.7%, P = 0.015). The mean TTC in women with PD was 7.1 months [confidence interval (CI): 5.7-8.6] compared with...Continue Reading

Associated Clinical Trials

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Oct 21, 2014·Annals of Medical and Health Sciences Research·So NwhatorT Sorsa
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Dec 18, 2020·Journal of Periodontology·Gul Yildiz TelatarBaris Can Telatar

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