Periodontal disease and liver cirrhosis: A systematic review

SAGE Open Medicine
Lea Ladegaard Grønkjær

Abstract

Studies suggest that periodontal disease, a source of subclinical and persistent infection, may be associated with various systemic conditions, including liver cirrhosis. The aim of this study was to examine the literature and determine the relationship between periodontal disease and liver cirrhosis and to identify opportunities and directions for future research in this area. A systematic review of English articles in the PubMed, EMBASE, and Scopus databases was conducted using search terms including 'liver cirrhosis', 'end-stage liver disease', 'liver diseases', 'oral health', 'periodontal disease', 'mouth disease', 'gingivitis', and 'periodontitis'. Thirteen studies published between 1981 and 2014 were found to include data on oral health and periodontal disease in cirrhotic patients. Studies indicated an increased incidence of periodontal disease in patients with liver cirrhosis, measured with several different periodontal indices. The reported prevalence of periodontal disease in cirrhosis patients ranged from 25.0% to 68.75% in four studies and apical periodontitis was found in 49%-79% of the patients. One study found that mortality was lower among patients who underwent dental treatment versus non-treated patients. Anot...Continue Reading

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Citations

Jul 14, 2018·Journal of Periodontology·Bruna Di ProfioClaudio Mendes Pannuti
Jan 29, 2019·Journal of Periodontology·Alexandru MesterRadu Septimiu Campian
Oct 10, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Jaana Helenius-HietalaFredrik Åberg
Jul 25, 2019·Journal of Clinical Periodontology·Fernando Oliveira CostaLuís Otávio Miranda Cota
Aug 18, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jasmohan S BajajSinem E Sahingur
Jan 22, 2020·Journal of Periodontology·Reza TalebianReinhard Gruber
Oct 22, 2019·Biomedical Reports·Yumiko Nagao, Takeshi Tanigawa
Mar 16, 2018·Experimental and Therapeutic Medicine·Li FengMing Lin
Oct 6, 2017·JCI Insight·Chathur AcharyaJasmohan S Bajaj
May 16, 2017·Journal of Periodontal Research·J Dos Santos CarvalhoD F P Vasconcelos
Jul 18, 2018·Scientific Reports·Anders JensenMogens Kilian
Apr 2, 2020·BMC Public Health·Cilia Mejia-LancherosPatricia O'Campo
May 1, 2021·Cancers·Se-Young ParkNa-Young Song
Aug 6, 2021·International Endodontic Journal·Cynthia Mireya JaraMaximiliano Schünke Gomes

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