Periodontal Disease and Risks of Kidney Function Decline and Mortality in Older People: A Community-Based Cohort Study

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Yung-Tai ChenTaiwan Geriatric Kidney Disease (TGKD) Research Group

Abstract

The association between periodontal disease and chronic kidney disease in older people is controversial, and evidence for a causal link between kidney function decline and subsequent mortality risk is limited. Longitudinal, observational, community-based cohort study. Participants were citizens 65 years or older who received the Taipei City Government-sponsored Annual Elderly Health Examination Program during 2005 to 2010, including dental status assessment and biochemical examinations. Participants with periodontal disease defined by the World Health Organization Community Periodontal Index of Treatment Need criteria. All-cause and cardiovascular mortality and estimated glomerular filtration rate (eGFR) decline ≥ 30% over 2 years. Of 100,263 study participants, 13,749 (13.7%) had periodontal disease. In a mean follow-up of 3.8 years, all-cause and cardiovascular mortality rates in those with periodontal disease (11.5% and 2.6%, respectively) were higher compared with those without periodontal disease (6.7% and 1.6%, respectively). After adjustment for demographic characteristics, comorbid conditions, and biochemistry data, adjusted HRs for all-cause and cardiovascular mortality were 1.34 (95% CI, 1.26-1.42) and 1.25 (95% CI, 1...Continue Reading

References

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Citations

Aug 13, 2015·Blood·Ming-Tsun TsaiUNKNOWN Taiwan Geriatric Kidney Disease Research Group
Jul 27, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Abhijit V Kshirsagar, Vanessa Grubbs
May 23, 2016·Journal of the American Medical Directors Association·Chia-Jen ShihUNKNOWN Taiwan Geriatric Kidney Disease (TGKD) Research Group
Oct 7, 2017·Journal of Clinical Periodontology·Masanori IwasakiHidetoshi Nakamura
Feb 15, 2018·Journal of the American Heart Association·Wei-Cheng TsengUNKNOWN Taiwan Geriatric Kidney Disease (TGKD) Research Group
Dec 13, 2018·Hypertension·Davide PietropaoliAnnalisa Monaco
Jan 24, 2018·Nephrology·Kostas KapellasUNKNOWN Perio-CKD collaboration
Mar 10, 2017·Journal of Clinical Periodontology·Yun-Chun WuYu-Kang Tu
Jul 24, 2018·Gerontology & Geriatric Medicine·Shaoqing GeXinQi Dong
Apr 18, 2019·Journal of Clinical Periodontology·Attawood LertpimonchaiAmmarin Thakkinstian
Feb 1, 2019·Scientific Reports·Wei-Cheng TsengUNKNOWN Taiwan Geriatric Kidney Disease (TGKD) Research Group

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