Periodontal Diseases as Putative Risk Factors for Head and Neck Cancer: Systematic Review and Meta-Analysis

Cancers
Divya GopinathNewell W Johnson

Abstract

Whether "periodontal disease" can be considered as an independent risk factor for head and neck cancer (HNC) remains controversial. The aim of the current meta-analysis was to quantitatively assess this relationship in order to determine whether this represents a true risk factor, with implications for cancer prevention and management. PubMed, Scopus, and Embase databases were systematically searched. Selective studies were reviewed, and meta-analysis was performed to estimate the pooled odds ratio (OR) with 95% confidence intervals (CIs) on eligible studies using a random effects model. In total, 21 eligible observational studies (4 cohorts and 17 case-controls) were identified for qualitative synthesis after a review of 1051 articles. Significant heterogeneity could be identified in measures utilized for reporting of periodontal disease. Meta-analysis performed on nine studies that employed objective measures for reporting periodontal disease demonstrated a significant association between periodontal disease and HNC [OR 3.17, 95% CI, 1.78-5.64]. A diseased periodontium represents an independent risk marker, and a putative risk factor, for HNC. Prospective studies with standardized measures of periodontal disease severity and ...Continue Reading

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Citations

Jan 15, 2021·Scientific Reports·Divya GopinathNewell W Johnson
Jan 5, 2021·Journal of Oral Microbiology·Divya GopinathNewell W Johnson
Apr 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel
Aug 27, 2021·Clinical Oral Investigations·Divya GopinathNewell W Johnson

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