Periodontal infection with Porphyromonas gingivalis induces preterm birth and lower birth weight in rats

Molecular Oral Microbiology
S LiangMinquan Du

Abstract

Preterm birth (PTB), accompanied by low birth weight (LBW) or not, is a syndrome with tremendous risk factors and long-term health consequences for children. In recent decades, overwhelming studies have shown that periodontitis contributes to prematurity and LBW. This study was conducted to determine the link between maternal periodontitis and the pathogenesis of PTB and/or LBW through a rat infection model induced by Porphyromonas gingivalis, an important periodontopathic bacterium. The murine model was established by surgically ligating the left mandibular first molars and inoculating with P. gingivalis, and then all female rats initiated mating 6 weeks post infection. The gestational day and birth weight were recorded, and blood, amniotic fluid, and placental specimens were collected. Rats with a PTB and LBW newborns were observed in the P. gingivalis-infected group. Additionally, P. gingivalis infection significantly increased the maternal serum levels of interferon-γ and interleukin-1β, whereas no significant difference in the cytokine response was observed in the amniotic fluid. Moreover, with the translocation of P. gingivalis to placentas, remarkable changes in gestational tissues were found, followed by significantly e...Continue Reading

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Citations

Dec 22, 2020·Frontiers in Microbiology·Luz Amparo GómezGloria Inés Lafaurie
Jan 14, 2021·Scientific Reports·Kevin YuCharles E Wood
Jul 3, 2021·Pathogens·Milan TerzicAntonio Simone Laganà

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