Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study

Archives of Internal Medicine
Axel SpahrWolfgang Koenig

Abstract

Chronic inflammation from any source is associated with increased cardiovascular risk. Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects. A total of 789 subjects (263 patients with angiographically confirmed, stable CHD and 526 population-based, age- and sex-matched controls without a history of CHD) were included in the Coronary Event and Periodontal Disease (CORODONT) study. Subgingival biofilm samples were analyzed for periodontal pathogens Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia, and Treponema denticola using DNA-DNA hybridization. The need for periodontal treatment in each subject was assessed using the Community Periodontal Index of Treatment Needs (CPITN). The main outcome measures included total periodontal pathogen burden, number of the various periodontal pathogens in the subgingival biofilm, and periodontal treatment needs (according to the CPITN). In multivariable analyses, we found a statistically significant association between the periodontal pathogen burden (log10 of the sum of all pathogens) (odds ra...Continue Reading

Citations

Oct 14, 2011·Journal of Women's Health·Sindhu K Srinivas, Samuel Parry
Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Michal StrakaViera Mongiellova
Jan 5, 2012·Antimicrobial Agents and Chemotherapy·Stuart G DashperEric C Reynolds
Feb 15, 2012·Antimicrobial Agents and Chemotherapy·Kabilan VelliyagounderDaniel H Fine
Jun 26, 2012·BMC Oral Health·Dirk ZiebolzRainer F Mausberg
Sep 4, 2008·Journal of Periodontology·Paul M Ridker, Josh D Silvertown
Jun 3, 2009·Journal of Periodontology·Heather JaredSteven Offenbacher
Oct 2, 2009·Journal of Periodontology·Jamal M SteinRalf Smeets
Oct 2, 2009·Journal of Periodontology·Syed Akhtar Hussain BokhariMateen Izhar
Feb 14, 2012·Journal of Periodontology·Javed AshrafAyyaz Ali Khan
May 20, 2009·Epidemiology and Infection·A SteptoeB Henderson
Jul 9, 2010·Teaching and Learning in Medicine·Jorge Hernán RamirezAdolfo Contreras
Oct 16, 2015·Journal of Clinical Periodontology·Audrey SchmittPhilippe Bouchard
Apr 17, 2007·Annals of the New York Academy of Sciences·David R Jacobs, Richard S Crow
Jan 30, 2007·Journal of Clinical Periodontology·Farnaz TabriziBjörn Klinge
Sep 9, 2008·Journal of Clinical Periodontology·Gösta Rutger Persson, Rigmor Elisabeth Persson
Aug 23, 2007·The British Journal of Dermatology·S EkqvistM Bruze
Mar 26, 2013·Journal of Clinical Periodontology·Päivi MäntyläPirkko J Pussinen
Apr 27, 2011·Journal of the American Academy of Nurse Practitioners·Nancy J CibulkaRebecca Sarabia
Nov 4, 2011·Immunopharmacology and Immunotoxicology·Asuka FukasawaMasafumi Yamamoto
Sep 6, 2013·Immunological Investigations·Srinivas R MyneniAshu Sharma
Apr 13, 2015·International Journal of Cardiology·Damian Sanchez-TorresMartin Laclaustra
Jan 26, 2010·Metabolism: Clinical and Experimental·Robert BerentSerge P von Duvillard
Dec 28, 2011·Microbes and Infection·Daniel BelstrømPalle Holmstrup
Sep 22, 2010·Journal of Applied Oral Science : Revista FOB·Sérgio Aparecido TorresWalter Antônio Bretz
Mar 28, 2017·International Journal of Cardiology·Shogo MatsuiYukihito Higashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.