Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Oliver LaugischSigrun Eick

Abstract

Recent studies suggest a link between periodontitis and Alzheimer's disease (AD). Verification of the presence of periodontal pathogens and the intrathecal generation of pathogen-specific antibodies in 20 patients with AD and 20 with other forms of dementia (DEM-noAD). Clinical periodontal indices were recorded. Cerebrospinal fluid (CSF) was analyzed for total tau protein (T-tau) and amyloid-β (Aβ1-42). In serum and CSF, antibody levels against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema species were quantified. The presence of selected bacteria and inflammatory biomarkers were determined in periodontium, serum, and CSF. In line with diagnoses, CSF-levels of Aβ1-42 were significantly lower in AD than DEM-noAD patients. Periodontal destruction and inflammation were omnipresent with no difference between groups. P. gingivalis, T. forsythia, and Treponema species were detected in more than 50% of subgingival biofilm samples, but neither in serum nor in the CSF. Elevated levels of anti-pathogen antibodies in CSF of 16 patients (7 AD; 9 DEM-noAD) compared to serum highlight a possibility of the intrathecal immune response to pathogens. There was no significant difference in antibodies levels agains...Continue Reading

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Citations

Feb 26, 2020·Current Opinion in Neurology·Mahtab SadrameliLavinia Alberi
May 28, 2020·Journal of Dental Research·S E KleinsteinM Freire
Dec 24, 2019·Frontiers in Cellular and Infection Microbiology·Zhong SunKaruppiah Thilakavathy
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Jul 25, 2019·Journal of Clinical Medicine·Jan OscarssonAnders Johansson
Jan 14, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mohsin AminKathryn A Whitehead
Aug 20, 2021·Odontology·Steeve BregaintAnne Jolivet-Gougeon
Sep 1, 2021·Periodontology 2000·Mark I Ryder, Pinelopi Xenoudi
Oct 27, 2021·Oral Diseases·Valeria Parra-TorresJaime Díaz-Zúñiga

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