Periodontal regeneration: focus on growth and differentiation factors

Dental Clinics of North America
Jaebum LeeUlf M E Wikesjö

Abstract

Several growth and differentiation factors have shown potential as therapeutic agents to support periodontal wound healing/regeneration, although optimal dosage, release kinetics, and suitable delivery systems are still unknown. Experimental variables, including delivery systems, dose, and the common use of poorly characterized preclinical models, make it difficult to discern the genuine efficacy of each of these factors. Only a few growth and differentiation factors have reached clinical evaluation. It appears that well-defined discriminating preclinical models followed by well-designed clinical trials are needed to further investigate the true potential of these and other candidate factors. Thus, current research is focused on finding relevant growth and differentiation factors, optimal dosages, and the best approaches for delivery to develop clinically meaningful therapies in patient-centered settings.

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Citations

Dec 15, 2010·Journal of Periodontology·Zhao LinWilliam V Giannobile
Jan 8, 2013·Journal of Periodontology·Eduardo AnituaGorka Orive
Dec 7, 2011·Medicina oral, patología oral y cirugía bucal·S SoodA Mahendra
May 26, 2012·Journal of Indian Society of Periodontology·S J ManoranjanV Ranganath
Apr 14, 2015·Periodontology 2000·Anton SculeanWilliam V Giannobile
Apr 14, 2015·Periodontology 2000·Cristiano SusinUlf M E Wikesjö
Feb 4, 2011·Expert Opinion on Biological Therapy·Darnell KaiglerWilliam V Giannobile
Jul 15, 2015·Experimental and Therapeutic Medicine·Marzena Wyganowska-ŚwiątkowskaJerzy Jankun
Oct 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fa-Ming ChenMin Zhang
Sep 14, 2011·Biotechnology Progress·Hai-Hua SunFa-Ming Chen
Apr 12, 2013·Periodontology 2000·Cristiano Susin, Ulf M E Wikesjö
Jan 30, 2013·Pharmaceutical Development and Technology·Sabrina Barbosa de Souza FerreiraMarcos Luciano Bruschi
Apr 5, 2014·BioMed Research International·Yinghong ZhouYin Xiao
Dec 30, 2014·Archives of Oral Biology·Khushboo GuptaKavita Nitish Garg
Nov 3, 2010·Journal of Dental Research·M Somerman
Dec 9, 2010·Chemical & Pharmaceutical Bulletin·Yasuhiko SatoKazumi Danjo
Jan 21, 2020·Regenerative Medicine·Muhammad S ShaikhMuhammad S Zafar
Jun 4, 2020·The Journal of Craniofacial Surgery·Jungwon LeeYong-Moo Lee
Nov 19, 2011·Journal of Clinical Periodontology·Andreas StavropoulosUlf M E Wikesjö
May 23, 2019·Current Pharmaceutical Design·Ying YanJianer Chen
Jun 12, 2017·International Journal of Biological Macromolecules·Tuğba DuruelMenemşe Gümüşderelioğlu

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