Periodontal regeneration using an injectable bone cement combined with BMP-2 or FGF-2

Journal of Tissue Engineering and Regenerative Medicine
Daniël A W OortgiesenJohn A Jansen

Abstract

Periodontitis is a frequently diagnosed oral disease characterized by bone resorption and soft tissue loss around teeth. Unfortunately, currently available therapies only slow or arrest progress of the disease. Ideally, treatment of periodontal defects should be focused on complete regeneration of the lost tissues [(bone and periodontal ligament (PDL)]. As a result, this study used intrabony defects to evaluate the regenerative potential of an injectable macroporous calcium phosphate cement (CaP) in combination with bone morphogenetic protein-2 (BMP-2) or fibroblast growth factor-2 (FGF-2). After creating 30 periodontal defects in 15 Wistar rats, three treatment strategies were conducted: application of CaP only, CaP + BMP-2 and CaP + FGF-2. Animals were euthanized after 12 weeks and processed for histology and histomorphometry. Using CaP alone resulted in limited effects on PDL and bone healing. CaP + BMP-2 showed a good response for bone healing; a significant 2.4 fold increase in bone healing score was observed compared to CaP. However, for PDL healing, CaP + BMP-2 treatment showed no difference compared to the CaP group. The best results were observed with the combined treatment of CaP + FGF-2, which showed a significant 3....Continue Reading

References

May 1, 1976·Journal of Periodontology·A H Melcher
Jul 1, 1982·Journal of Clinical Periodontology·S NymanH Rylander
Oct 6, 1997·Journal of Clinical Periodontology·S GestreliusL Hammarström
Feb 24, 2000·Journal of Periodontal Research·S MurakamiH Okada
Sep 26, 2002·Journal of Periodontology·Knut A SelvigUlf M E Wikesjö
Aug 18, 2004·Journal of Clinical Periodontology·Rachel G SorensenJohn M Wozney
Oct 22, 2005·Orthodontics & Craniofacial Research·M TabaW V Giannobile
Nov 11, 2006·Journal of Biomaterials Science. Polymer Edition·W J E M HabrakenJ A Jansen
Jan 18, 2008·Journal of Biomedical Materials Research. Part a·Dennis P LinkJohn A Jansen
Jun 4, 2008·Journal of Biomedical Materials Research. Part a·Dennis P LinkJohn A Jansen
Aug 30, 2008·Journal of Biomaterials Science. Polymer Edition·W J E M HabrakenJ A Jansen
Jun 21, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Milan TomkaJarmila Procházková

❮ Previous
Next ❯

Citations

Dec 3, 2014·Trends in Pharmacological Sciences·Witek KwiatkowskiSenyon Choe
Apr 11, 2015·Stem Cells International·Wenjun Zhu, Min Liang
Nov 27, 2015·Journal of Dental Research·L LarssonW V Giannobile
Mar 23, 2018·International Journal of Molecular Sciences·Beatriz Hernández-MonjarazVíctor Manuel Mendoza-Núñez
Jun 2, 2017·Journal of Biomaterials Science. Polymer Edition·Soo Hyon LeeYadong Wang
Aug 24, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ryo JimboPaulo G Coelho
Nov 6, 2018·Current Stem Cell Research & Therapy·Dilcele Silva Moreira DziedzicKatherine Athayde Teixeira de Carvalho
Jun 10, 2020·International Journal of Molecular Sciences·Juliana BaranovaEdda Tobiasch
Aug 24, 2017·Journal of Tissue Engineering and Regenerative Medicine·Pedro S BaboX Frank Walboomers
Dec 21, 2017·Inflammation and Regeneration·Pornkawee CharoenlarpSachiko Iseki
May 17, 2013·Journal of Clinical Periodontology·Na YuJohn A Jansen
May 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pedro S BaboManuela E Gomes
Jan 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingou LiangLei Cheng
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Tie LiuYuelian Liu
Sep 29, 2020·Journal of Oral Biology and Craniofacial Research·Aya Anwar AlsherifDoaa Ameen Taiema
Oct 29, 2020·Archives of Oral Biology·Céline StutzOlivier Huck
Sep 30, 2021·Journal of Tissue Engineering and Regenerative Medicine·Shahnawaz KhijmatgarMassimo Del Fabbro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.