Periodontal regeneration via chemoattractive constructs

Journal of Clinical Periodontology
Xinjie CaiAdelina S Plachokova

Abstract

Chemoattractants, such as stromal cell-derived factor-1α (SDF-1α), can offer an advantage for periodontal regeneration by recruiting the patient's own stem cells to stimulate self-repair. We here developed a chemoattractive construct for periodontal regeneration using SDF-1α and evaluated its efficacy in vivo. SDF-1α was loaded on gelatin sponge and tested in vitro for SDF-1α release. Subsequently, SDF-1α constructs were implanted into rat periodontal defects for 1 and 6 weeks, with unloaded materials and empty defects as controls. The regenerative efficacy was evaluated by micro-CT, histological and histomorphometrical analyses. In vitro results showed limited SDF-1α release up to 35 days. In contrast, SDF-1α constructs significantly improved periodontal defect regeneration in terms of alveolar bone height, new bone area and functional ligament length. Additionally, SDF-1α constructs decreased the inflammatory response at Week 6. Chemoattractive constructs significantly improved periodontal regeneration in terms of alveolar bone height, new bone area and functional ligament length.

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Citations

Jan 21, 2020·Regenerative Medicine·Muhammad S ShaikhMuhammad S Zafar
Aug 20, 2019·International Journal of Oral Science·Chenxi ZhengYan Jin
Mar 19, 2021·Journal of Periodontal Research·Sema S HakkiSeyit Ali Kayis
Sep 29, 2021·Chemical Biology & Drug Design·Sadaf Ul HassanAysha Mohyuddin

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