Periodontal repair in dogs: effect of allogenic freeze-dried demineralized bone matrix implants on alveolar bone and cementum regeneration

Journal of Periodontology
C K KimU M Wikesjö

Abstract

The objective of this study was to evaluate alveolar bone and cementum regeneration following surgical placement of an allogenic, freeze-dried, demineralized bone matrix (DBM) cortical strip implant. Critical size, supraalveolar periodontal defects were surgically created around the second, third, and fourth mandibular premolar teeth in eight mongrel dogs. Contralateral jaw quadrants in six animals were randomly assigned to receive the DBM implant, or serve as surgical control. Two additional animals received bilateral DBM implants. Flaps were coronally advanced to submerge teeth and implants, and sutured. Three animals were exited from the study due to extensive early wound failure. Remaining animals were sacrificed at 8 weeks postsurgery. Histometric recordings included defect height, bone regeneration/DBM implant height, cementum regeneration height, root resorption, and ankylosis. Large areas of unresorbed DBM exhibiting fragmentation and empty osteocyte lacunae were observed adjacent to new bone formation, or bone formation was observed adjacent to or within the implant, often exhibiting ankylosis. Cementum regeneration appeared enhanced in shelter of the DBM implant. Histometric recordings (mean+/-SD) for DBM and control ...Continue Reading

References

Mar 1, 1976·Journal of Periodontology·J T MellonigJ J Lawrence
Jan 1, 1975·Journal of Periodontology·B M LibinL Fishman
Dec 1, 1992·Scandinavian Journal of Dental Research·E M PinholtG Bang
Jan 1, 1991·Journal of Clinical Periodontology·U M Wikesjö, R Nilvéus
Jan 1, 1991·Journal of Clinical Periodontology·U M WikesjöJ Egelberg
Dec 1, 1989·Journal of Periodontology·G M BowersE Romberg
Dec 1, 1989·Journal of Periodontology·G M BowersE Romberg
Dec 1, 1989·Journal of Periodontology·G M BowersE Romberg
Aug 1, 1988·The Journal of Bone and Joint Surgery. British Volume·P AspenbergK G Thorngren
Aug 1, 1967·Archives of Oral Biology·J D Yeomans, M R Urist
Nov 12, 1965·Science·M R Urist
May 1, 1983·Stain Technology·P J McMillanJ McMillan
Dec 1, 1994·Clinical Oral Implants Research·E M PinholtG Bang
Sep 15, 1993·Spine·S R FrenkelA B Prewett
Feb 1, 1996·Journal of Periodontology·M A Reynolds, G M Bowers

❮ Previous
Next ❯

Citations

Dec 30, 2009·Oral and Maxillofacial Surgery·Ahmet Atila ErtanMurat Cavit Cehreli
Nov 24, 2006·Journal of Materials Science. Materials in Medicine·D BoixG Grimandi
Apr 14, 2015·Periodontology 2000·Cristiano SusinUlf M E Wikesjö
Aug 18, 2004·Journal of Clinical Periodontology·Rachel G SorensenJohn M Wozney
Apr 12, 2013·Periodontology 2000·Cristiano Susin, Ulf M E Wikesjö
Sep 20, 2011·International Journal of Oral and Maxillofacial Surgery·F V RibeiroM Z Casati
Jan 28, 2003·Journal of Periodontology·Hyun-Young KimChong-Kwan Kim
May 12, 2006·Periodontology 2000·Giuseppe PolimeniUlf M E Wikesjö
Apr 11, 2003·Clinical Implant Dentistry and Related Research·Ulf M E WikesjöJohn M Wozney
Jun 18, 2010·The Open Dentistry Journal·Xavier StruillouPierre Layrolle
Jun 6, 2019·Clinical Oral Investigations·Oliver LaugischAnton Sculean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.