Periodontal tissue disposition of azithromycin

Journal of Periodontology
T MaliziaMario Del Tacca

Abstract

The tissue penetration of azithromycin, the prototype of a new class of macrolide antibiotics named azalides, was studied in patients undergoing surgery for third-molar removal. Drug concentrations in plasma, saliva, and periodontal tissues were evaluated in 28 patients treated with azithromycin 500 mg/day per os for 3 consecutive days. Samples of blood, saliva, gingiva, and alveolar bone were collected during oral surgery, 12 hours, and 2.5, 4.5, and 6.5 days after the last dosing, and the azithromycin concentration was measured microbiologically by using Micrococcus luteus NCTC 8440 as the reference organism. The highest concentrations of azithromycin were observed 12 hours after the last dose in plasma, saliva, gingiva, and bone (0.33 +/- 0.04 mg/l, 2.14 +/- 0.30 mg/l, 6.47 +/- 0.57 mg/kg, and 1.86 +/- 0.15 mg/kg, respectively) and then declined gradually. However, consistent levels of the drug in saliva and periodontal tissues could be detected up to 6.5 days, indicating that azithromycin was retained in target tissues and fluids for a long time after the end of treatment. Among the samples examined, the highest concentration of azithromycin was found in the gingiva at each time studied. Moreover, the ratios of salivary or ...Continue Reading

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Citations

Aug 18, 2004·British Dental Journal·L D Addy, M V Martin
Dec 22, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G MumcuH Direskeneli
Jul 25, 2008·Journal of Dental Research·C-H Chou, J D Walters
Mar 23, 2011·Journal of Periodontology·Pin-Chuang LaiJohn D Walters
Oct 16, 2012·Journal of Pharmacy & Bioallied Sciences·Abinaya PrakasamRavi Kumar Natarajan
Sep 9, 2008·Journal of Clinical Periodontology·David HerreraMariano Sanz
Mar 1, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kohji IshihamaYukihiro Ota
Apr 29, 2005·Journal of Periodontology·Paulo MascarenhasHom-Lay Wang
May 2, 2007·Journal of Periodontology·Kazuhiro GomiTakashi Arai
May 16, 2002·Periodontology 2000·Jørgen Slots, Miriam Ting
Feb 5, 2016·Clinical and Experimental Dental Research·Pin-Chuang Lai, John D Walters
Mar 11, 2009·Clinical Pharmacokinetics·Cornelia B LandersdorferFritz Sörgel
Dec 25, 2019·British Dental Journal·Martin H ThornhillLarry M Baddour

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