Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs.

Journal of Periodontal & Implant Science
Jung-Seok LeeSeong-Ho Choi

Abstract

This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.

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Citations

Sep 18, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Xana Raquel OrtolanFátima de Campos Buzzi
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·João Filipe RequichaManuela Estima Gomes
Feb 9, 2018·Nanomedicine·Rafał PokrowieckiAgnieszka Mielczarek
Mar 19, 2020·International Journal of Molecular Sciences·Hun-Jin JeongSeung-Jae Lee
Jul 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yinghong ZhouYin Xiao
Apr 27, 2021·Connective Tissue Research·Kemal Burak ŞahbazoğluFerda Alev Akalın

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