Abstract
Periodontitis is an oral inflammatory disease affecting the teeth supportive tissue. Its bacterial infectious etiology is well established. Periodontitis has been associated with increased prevalence of systemic diseases such as cardiovascular diseases, diabetes, rheumatoid arthritis, preeclampsia, preterm birth and inflammatory bowel disease. The rational of considering periodontitis as risk factor for systemic disease is the passage of inflammatory cytokines and/or bacteria in the bloodstream, thus affecting distant organs. Membrane microparticles are released by multiple cells in inflammatory environment. Recent data suggested the role of these microparticles in the pathogenic process of many systemic diseases, that can be also associated to periodontitis. We hypothesized that periodontitis could be a chronic reservoir of microparticles, hence elucidating partially the interaction with systemic diseases initiation or progression.
References
Jan 7, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ingrid MüllerBernd Engelmann
Nov 13, 2010·Journal of Clinical Periodontology·Alina KunnenMarijke M Faas
Nov 30, 2010·European Journal of Internal Medicine·Giuseppe PizzoGiuseppina Campisi
May 17, 2011·European Journal of Internal Medicine·Arnon Blum
Jul 29, 2011·Trends in Pharmacological Sciences·Maria Carmen MartinezRamaroson Andriantsitohaina
Dec 3, 2011·Periodontology 2000·Brenda Heaton, Thomas Dietrich
Dec 20, 2012·Clinical Science·Dylan BurgerRhian M Touyz
Mar 26, 2013·Journal of Dental Research·S KaurP M Bartold
Sep 11, 2013·PloS One·Daniela LeonettiRamaroson Andriantsitohaina
Jan 25, 2014·Current Rheumatology Reports·Joanna KozielJan Potempa
May 16, 2014·Blood Reviews·Thierry BurnoufMirjana Radosevic
Citations
Sep 9, 2015·Mediators of Inflammation·Vilana Maria Adriano AraújoVilma Lima
May 18, 2016·Scientific Reports·JiaLi YinChun Hung Chu
Jun 29, 2016·Journal of Oral Science·Xianrui YangDing Bai
Jun 29, 2017·Medicine·Jae-Hong LeeSeong-Ho Choi
Sep 9, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Oct 1, 2020·Journal of Periodontal Research·Huixu LiShu Li
Mar 6, 2019·International Journal of Environmental Research and Public Health·Chien-Yu LinRen-Jun Hsu
Mar 24, 2018·BMC Oral Health·Tine B SivertsenMarit S Skeie
Mar 28, 2019·Current Osteoporosis Reports·Miao ZhouJanak L Pathak
Nov 25, 2018·International Journal of Environmental Research and Public Health·Chien-Yu LinRen-Jun Hsu
Jul 28, 2020·International Journal of Molecular Sciences·Hideki KitauraItaru Mizoguchi
Sep 16, 2017·Experimental and Therapeutic Medicine·Dongmei ZhangYaping Pan
Dec 17, 2020·International Journal of Environmental Research and Public Health·Kumar Chandan SrivastavaMohammad Khursheed Alam
Dec 23, 2020·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Nithimar Sermsuti-Anuwat, Sathirakorn Pongpanich
Oct 12, 2019·Microorganisms·Denis BourgeoisFlorence Carrouel
Jun 23, 2021·Journal of Periodontology·Nan ZuoJialan Shi
Aug 6, 2021·Archives of Oral Biology·Panpan YangMinqi Li
Nov 7, 2021·Oral Diseases·Yuying KouMinqi Li