Periodontitis deteriorates metabolic control in type 2 diabetic Goto-Kakizaki rats

Journal of Periodontology
Carla C Pontes AndersenPalle Holmstrup

Abstract

Epidemiologic and clinical studies have indicated that periodontal disease (PD) may cause disturbances in general health and even affect diabetes. The aim of this study was to gain knowledge on the effect of PD on diabetes metabolic control in a new model for type 2 diabetes-associated PD (i.e., the Goto-Kakizaki [GK] rat). GK rats represented the type 2 diabetes group and were allocated into two groups: diabetes or diabetes+PD group; Wistar rats represented the non-diabetes group and were divided into non-diabetes+PD and non-diabetes groups. PD was induced by placing ligatures around second maxillary molars, and the animals were followed for 6 weeks. Serum insulin, glucose, and free fatty acid levels were evaluated; interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha were measured in adipose tissue supernatant; glucose tolerance and insulin resistance were calculated. Further, alveolar bone destruction was estimated morphometrically and radiographically. Rats with diabetes+PD became almost 30% more glucose intolerant (P<0.01) and presented a 25% increase in IL-1beta in adipose tissue (P<0.05) compared to rats from the diabetes group. Moreover, PD associated with diabetes resulted in more alveolar bone destruction in ...Continue Reading

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Citations

Sep 22, 2007·Journal of Hypertension·Henry VölzkeThomas Kocher
Apr 15, 2010·Journal of Lipid Research·So-Ra OhHye-Seon Choi
Dec 20, 2007·PloS One·Marcela ClaudinoGerson Francisco de Assis
Mar 6, 2007·Journal of Periodontology·Carla C Pontes AndersenPalle Holmstrup
Jul 5, 2007·Journal of Periodontology·Carla C Pontes AndersenPalle Holmstrup
Dec 7, 2007·Journal of Periodontology·A SchulzeM Busse
Aug 7, 2009·Journal of Periodontology·Johanne KongstadPalle Holmstrup
Nov 18, 2011·Journal of Periodontology·Natalia H ColomboDoris H Sumida
Jun 19, 2012·Journal of Periodontology·Daisy J ShirakashiDoris H Sumida
Dec 29, 2009·Journal of Electrocardiology·Guang YuRong Shu
Mar 15, 2016·Journal of Periodontal Research·M B GrauballeP Holmstrup
Aug 11, 2015·Journal of Clinical Periodontology·Morten Bay GrauballePalle Holmstrup
Sep 8, 2010·Veterinary Pathology·T SanoI Narama
Mar 5, 2010·Journal of Dental Research·R GaspersicU Skaleric
Aug 6, 2021·International Endodontic Journal·Cynthia Mireya JaraMaximiliano Schünke Gomes

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