Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery

The Cochrane Database of Systematic Reviews
Hermann BlessbergerClemens Steinwender

Abstract

Randomized controlled trials (RCTs) have yielded conflicting results regarding the ability of beta-blockers to influence perioperative cardiovascular morbidity and mortality. Thus routine prescription of these drugs in an unselected population remains a controversial issue. A previous version of this review assessing the effectiveness of perioperative beta-blockers in cardiac and non-cardiac surgery was last published in 2018. The previous review has now been split into two reviews according to type of surgery. This is an update, and assesses the evidence in non-cardiac surgery only. To assess the effectiveness of perioperatively administered beta-blockers for the prevention of surgery-related mortality and morbidity in adults undergoing non-cardiac surgery. We searched CENTRAL, MEDLINE, Embase, CINAHL, Biosis Previews and Conference Proceedings Citation Index-Science on 28 June 2019. We searched clinical trials registers and grey literature, and conducted backward- and forward-citation searching of relevant articles. We included RCTs and quasi-randomized studies comparing beta-blockers with a control (placebo or standard care) administered during the perioperative period to adults undergoing non-cardiac surgery. If studies inc...Continue Reading

References

May 1, 1992·American Journal of Perinatology·C QuashieR Bolognese
Oct 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D R MillerJ Hill
Oct 1, 1991·British Journal of Anaesthesia·K MikawaH Obara
Mar 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D OxornJ Hill
Jan 1, 1990·Anesthesiology·D T Mangano
Dec 1, 1988·Clinical Pharmacology and Therapeutics·B E GibsonR F Cucchiara
Sep 1, 1988·British Journal of Anaesthesia·J M BurnsW S Hillis
Mar 1, 1986·British Journal of Anaesthesia·J MagnussonD Thomson
Mar 1, 1986·British Journal of Anaesthesia·C J JakobsenB Christensen
Jul 1, 1973·British Journal of Anaesthesia·W RyderP B Gorman
Nov 1, 1984·Canadian Anaesthetists' Society Journal·A M SafwatD C Bilton
Apr 1, 1983·American Heart Journal·P Ward-BoothS Hillis
Aug 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S SharmaR Kalra
May 15, 1997·The New England Journal of Medicine·T HoG McAnulty
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jan 9, 1998·Acta Anaesthesiologica Scandinavica·C J JakobsenB Rasmussen
Mar 23, 1999·The Annals of Thoracic Surgery·C D BayliffR S Kennedy
Aug 7, 1999·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·D H Taylor
Nov 28, 2002·British Journal of Anaesthesia·C MenigauxM Chauvin
Sep 6, 2003·BMJ : British Medical Journal·Julian Pt HigginsDouglas G Altman
Nov 25, 2003·Anesthesia and Analgesia·Paul F WhiteAlexander Sloninsky
Mar 9, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Akinori YamazakiYoshio Hatano
Nov 2, 2005·Journal of Anesthesia·Toru GoyagiToshiaki Nishikawa
Jun 13, 2006·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·W D NearyJ J Earnshaw
May 6, 2008·BMJ : British Medical Journal·Gordon GuyattGRADE Working Group
Dec 17, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Benjamas Apipan, Duangdee Rummasak
Feb 2, 2010·Journal of Neurosurgical Anesthesiology·Masahiko KawaguchiIntraoperative Landiolol for Intracranial Aneurysm Surgery Trial (ILAST) Investigators
Sep 14, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Xiangying MengXiuli Wang
Jun 3, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E J BakkerD Poldermans
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon GuyattGRADE Working Group
Aug 16, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Nov 29, 2011·The Journal of International Medical Research·Y E MoonJ Lee
Apr 5, 2012·Korean journal of anesthesiology·Hyun-Seok DoSang-Jin Park
May 29, 2012·Current Pharmaceutical Design·Christoph MuhtzMichael Kellner
Jun 19, 2012·Breast Cancer Research and Treatment·David W CesconPamela J Goodwin
Aug 14, 2012·The American Journal of Medicine·Vineet Chopra, Kim A Eagle
Feb 19, 2014·Anesthesiology·Fernando BottoVascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators
Aug 12, 2014·European Heart Journal·Steen D Kristensen, Juhani Knuuti
Sep 19, 2014·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Oct 16, 2014·The Cochrane Database of Systematic Reviews·Luiz Gustavo De LimaEdina M K da Silva
Nov 12, 2014·Journal of Clinical and Diagnostic Research : JCDR·Vinod HosalliChhaya Joshi
May 6, 2015·Critical Care : the Official Journal of the Critical Care Forum·Arham AliCeleste C Finnerty
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Dec 3, 2015·The New England Journal of Medicine·P J Devereaux, Daniel I Sessler
Apr 24, 2016·British Journal of Anaesthesia·P S MylesCOMPAC-StEP Group
Apr 1, 2014·Turkish Journal of Anaesthesiology and Reanimation·Murat Alp AlkayaFevzi Yılmaz Göğüş
Jan 21, 2017·The Cochrane Database of Systematic Reviews·Charles S WiysongeLionel H Opie
Mar 17, 2017·Journal of Caring Sciences·Mohammad ZirakEbrahim Aliafsari Mamaghani
Aug 15, 2017·The Cochrane Database of Systematic Reviews·Ana-Marija HristovskaArash Afshari
Jan 10, 2018·Anaesthesia·D SellersG Djaiani
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Dallas DuncanDuminda N Wijeysundera
Mar 14, 2018·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Jun 24, 2018·Journal of Cardiothoracic and Vascular Anesthesia·Adriana D OpreaMiklos D Kertai
Jun 25, 2018·British Journal of Anaesthesia·M E JørgensenR D Sanders
Oct 24, 2019·The Cochrane Database of Systematic Reviews·Miranda CumpstonJames Thomas

Citations

Sep 24, 2019·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender

Related Concepts

Adrenergic beta-Antagonists
General Anesthesia
Cardiac Arrhythmia
Bradycardia
Cause of Death
Hypotension
Morbidity - Disease Rate
Myocardial Infarction
Postoperative Complications
Quality of Life

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