PMID: 9438739Jan 23, 1998Paper

Perioperative blood transfusion and postoperative mortality

JAMA : the Journal of the American Medical Association
J L CarsonB L Strom

Abstract

The risks of blood transfusion have been studied extensively but the benefits and the hemoglobin concentration at which patients should receive a transfusion have not. To determine the effect of perioperative transfusion on 30- and 90-day postoperative mortality. Retrospective cohort study. A total of 20 US hospitals between 1983 and 1993. A total of 8787 consecutive hip fracture patients, aged 60 years or older, who underwent surgical repair. Primary outcome was 30-day postoperative mortality; secondary outcome was 90-day postoperative mortality. The "trigger" hemoglobin level was defined as the lowest hemoglobin level prior to the first transfusion during the time period or, for patients in the nontranfused group, as the lowest hemoglobin level during the time period. Overall 30-day mortality was 4.6% (n=402; 95% confidence interval [CI], 4.1%-5.0%); overall 90-day mortality was 9.0% (n=788; 95% CI, 8.4%-9.6%). A total of 42% of patients (n=3699) received a postoperative transfusion. Among patients with trigger hemoglobin levels between 80 and 100 g/L (8.0 and 10.0 g/dL), 55.6% received a transfusion, while 90.5% of patients with hemoglobin levels less than 80 g/L (8.0 g/dL) received postoperative transfusions. Postoperative ...Continue Reading

Associated Clinical Trials

Oct 29, 2014·Andrew G Hill, MBChB, MD (Thesis), EdD, FACS, FRACSAndrew G Hill, MBChB, MD (Thesis), EdD, FACS, FRACS

Citations

Apr 20, 2006·Journal of Thrombosis and Thrombolysis·Katie M TwomleyRichard C Becker
Sep 29, 2005·Hematology·Jeffrey L Carson, Richard C Reynolds
Aug 28, 2003·Southern Medical Journal·Marian Petrides
Apr 17, 2014·International Journal of Colorectal Disease·Yasmin Abu-GhanemShmuel Avital
Apr 12, 2001·Critical Care : the Official Journal of the Critical Care Forum·M T Haupt
Jan 10, 2002·Journal of Orthopaedic Trauma·Konrad I GrusonKenneth J Koval
Jun 24, 2004·Journal of Orthopaedic Trauma·Ethan A HalmAlbert L Siu
Nov 16, 2006·Journal of Orthopaedic Trauma·P JohnstonM J Parker
Jan 5, 2006·Journal of General Internal Medicine·Mary Ann McLaughlinAlbert L Siu
Sep 7, 2002·Annals of the Royal College of Surgeons of England·S SharmaJ P Ivory
Dec 26, 2001·Annals of Surgery·Julian C L WongUNKNOWN ATIS Investigators
Jun 16, 2004·Critical Care : the Official Journal of the Critical Care Forum·Samir M Fakhry, Paola Fata
Mar 31, 2007·International Orthopaedics·Simon W YoungJohn A Skinner
Jul 30, 2014·The American Journal of Case Reports·Luiz Eduardo ImbelloniFrancisco Kartney Pedrosa
Sep 21, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mary H PalmerJeffrey L Carson
Aug 9, 2012·Internal and Emergency Medicine·Francesco CasellaUNKNOWN Gruppo di Autoformazione Metodologica (GrAM)
Aug 10, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F HardyS Bélisle
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G S Cooper
Mar 12, 2004·Surgical Infections·Michael G HughesRobert G Sawyer
Jun 1, 2005·Surgical Infections·Jeffrey L Carson
Dec 2, 2000·International Anesthesiology Clinics·M H Wall, R C Prielipp
Jun 19, 2004·International Anesthesiology Clinics·Kyung W Park, Dharmender Chandhok
Sep 19, 2002·American Journal of Therapeutics·Edward Crosby
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Jan 11, 2007·Current Opinion in Anaesthesiology·Alexander Kulier
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Oct 3, 2002·British Journal of Haematology·Judith C W Marsh, David H Bevan
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Jun 22, 2002·Transfusion·Melanie S KennedyUNKNOWN Viral Activation Transfusion Study Group
Sep 23, 2003·Critical Care Medicine·Jeffrey L Carson, Barbara Armas-Loughran

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