PMID: 8583079Sep 1, 1995Paper

Perioperative blood transfusion does not prevent recurrence in Crohn's disease. A pooled analysis

Journal of Clinical Gastroenterology
G L HollaarL R Sutherland

Abstract

The effect of perioperative blood transfusion on the recurrence of Crohn's disease is controversial. Various studies have suggested that perioperative blood transfusions reduce the risk of recurrence; others have failed to find a protective effect. Since all the studies are based on relatively small numbers, we performed a pooled analysis. We contacted the senior authors of seven previously published studies and asked for the original data. Four authors provided their data. The pooled database included 622 patients with a primary and complete resection of macroscopic disease. Recurrence was defined as the need for repeat surgery for disease control. Kaplan-Meier life table analysis was performed. Of the study sample, 366 cases (59%) were female. Disease distribution was as follows: small bowel (47%), small/large bowel (35%), and large bowel only (18%). Three hundred thirty-one patients (53%) received blood in the perioperative period. Mean follow-up was 72.8 months. For the overall sample, the 5-year recurrence rates were 26.9% for the transfused group and 25.2% for the nontransfused (p = 0.456). When the data were stratified by age, gender, disease location, and length of resection, no difference in 5-year recurrence rates bet...Continue Reading

Citations

Aug 20, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yi LiBo Shen
Jul 27, 2005·Inflammatory Bowel Diseases·Robert M PennerRichard N Fedorak
Jul 5, 2005·World Journal of Gastroenterology : WJG·Takayuki Yamamoto
Aug 11, 2011·Inflammatory Bowel Diseases·Peter De CruzPaul V Desmond
Jul 19, 2005·Annales de chirurgie·S Benoist

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