Perioperative dexmedetomidine for acute pain after abdominal surgery in adults

The Cochrane Database of Systematic Reviews
Luise Jessen LundorfAnn Merete Møller

Abstract

Acute postoperative pain is still an issue in patients undergoing abdominal surgery. Postoperative pain and side effects of analgesic treatment, in particular those of opioids, need to be minimized. Opioid-sparing analgesics, possibly including dexmedetomidine, seem a promising avenue by which to improve postoperative outcomes. Our primary aim was to determine the analgesic efficacy and opioid-sparing effect of perioperative dexmedetomidine for acute pain after abdominal surgery in adults.Secondary aims were to establish effects of dexmedetomidine on postoperative nausea and vomiting (PONV), gastrointestinal function and mobilization, together with the side effect profile of dexmedetomidine. We searched the following databases: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Institute for Scientific Information (ISI), Web of Science and Cumulative Index to Nursing and Allied Health Literature (CINAHL), and reference lists of articles to May 2014. We searched the Science Citation Index, ClinicalTrials.gov and Current Controlled Trials, and we contacted pharmaceutical companies to identify unpublished and ongoing studies. We applied no language restrictions. We reran the search in May 2015 and found nine studies ...Continue Reading

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Citations

Nov 4, 2017·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Sivendiran MahalingamJohn Penning
Jan 7, 2020·The British Journal of Surgery·C Small, H Laycock
Oct 23, 2019·BMC Anesthesiology·Venkatesan ThiruvenkatarajanRoelof M Van Wijk
Sep 30, 2020·The Korean Journal of Pain·Geun Joo ChoiJin Soo Ko
Apr 4, 2021·Healthcare·Sara J HylandRobert K Cleary
Aug 27, 2021·Experimental and Therapeutic Medicine·Wenyan ShanJitong Liu

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