Perioperative dynamics and significance of plasma-free amino acid profiles in colorectal cancer

BMC Surgery
Kayoko KatayamaManabu Shiozawa

Abstract

For early detection of cancer, we have previously developed the AminoIndex Cancer Screening (AICS) system, which quantifies 6 plasma-free amino acids (PFAAs) in blood samples. Herein, we examined the usefulness of the AICS in patients with colorectal cancer (CRC) by comparing the preoperative and postoperative PFAA profiles. Our study cohort consisted of 62 patients who had undergone curative resection for CRC at our cancer center, with no recurrence at the time of the study. Blood samples were collected from fasted patients within 1 week before the resection and at 0.5-6.5 years post-resection. Following plasmapheresis, the PFAA levels were measured via liquid chromatography/mass spectrometry, and the AICS values were computed (the higher the value, the greater the probability of cancer). Risk was calculated from the AICS value and ranked as A, B, or C, with rank C representing the highest risk. All patients in our study were rank B + C. The postoperative AICS value was lower than the preoperative value in 57 of the 62 patients; the rank was also lower postoperatively (49 patients, p < 0.001). The decline in both was stage-independent, even occurring in patients with right-sided tumors or poorly differentiated adenocarcinomas....Continue Reading

References

Jun 18, 2004·Cancer Investigation·Régine Minet-QuinardMarie-Paule Vasson
Jul 28, 2004·The American Journal of Clinical Nutrition·Giovanni RavagliaErminia Mariani
Feb 14, 2006·The American Journal of Clinical Nutrition·Yasushi NoguchiTakeshi Kimura
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Jan 28, 2015·Journal of Translational Medicine·Yu GuMin Wang
Feb 26, 2015·Journal of the National Cancer Institute·Fotios LoupakisHeinz-Josef Lenz
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Methods Mentioned

BETA
surgical resection
blood collection

Software Mentioned

AICS
R
GraphPad Prism

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