PMID: 9434694Jan 22, 1998Paper

Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants

The Journal of Thoracic and Cardiovascular Surgery
Adre du PlessisJane W Newburger

Abstract

In a randomized, single-center trial, we compared perioperative outcomes in infants undergoing cardiac operations after use of the alpha-stat versus pH-stat strategy during deep hypothermic cardiopulmonary bypass. Admission criteria included reparative cardiac surgery, age less than 9 months, birth weight 2.25 kg or more, and absence of associated congenital or acquired extracardiac disorders. Among the 182 infants in the study, diagnoses included D-transposition of the great arteries (n = 92), tetralogy of Fallot (n = 50), tetralogy of Fallot with pulmonary atresia (n = 6), ventricular septal defect (n = 20), truncus arteriosus (n = 8), complete atrioventricular canal (n = 4), and total anomalous pulmonary venous return (n = 2). Ninety patients were assigned to alpha-stat and 92 to pH-stat strategy. Early death occurred in four infants (2%), all in the alpha-stat group (p = 0.058). Postoperative electroencephalographic seizures occurred in five of 57 patients (9%) assigned to alpha-stat and one of 59 patients (2%) assigned to pH-stat strategy (p = 0.11). Clinical seizures occurred in four infants in the alpha-stat group (4%) and two infants in the pH-stat group (2%) (p = 0.44). First electroencephalographic activity returned s...Continue Reading

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Citations

Dec 4, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H L Pua, B Bissonnette
Dec 6, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory M T HareAndrew J Baker
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Jan 17, 2004·The Annals of Thoracic Surgery·Serena M CottrellJane W Newburger
Jul 1, 1998·The Annals of Thoracic Surgery·P R Hickey
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·David C BellingerJane W Newburger
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