Perioperative hypothalamic pituitary adrenal function in patients with silent corticotroph adenomas

Pituitary
Abdelle F CheresB M Arafah

Abstract

Silent corticotroph adenomas (SCAs) are characterized by strong ACTH immunostaining without clinical manifestations of hypercortisolism. Patients with SCAs often present with mechanical symptoms related to tumor growth. This study investigates the hypothalamic pituitary adrenal axis (HPA) characteristics after adenomectomy in patients with SCAs. Biochemical parameters of HPA function were monitored frequently after surgical resection of non-functioning macroadenomas. Levels of ACTH, cortisol, DHEA and DHEA-S were measured frequently for 48 h after adenomectomy. HPA data of patients with SCAs (n = 38) were compared to others (Controls) with non-secreting, ACTH-negative immunostaining adenomas of similar age and gender distribution (n = 182) who had adenomectomy. Plasma ACTH increased (P < 0.0001) equally in patients with SCA and controls reaching a peak at 3 h (238 ± 123 vs. 233 ± 96 ng/L, respectively) after extubation declining thereafter to baseline values 24-36 h. Similarly, serum cortisol levels increased (P < 0.0001) equally in both groups reaching a maximum at 7 h (36.8 ± 13.9 vs. 39.3 ± 13.3 ug/dL). Serum DHEA also increased (P < 0.001) equally in both groups in parallel to the rise in serum cortisol. Serum DHEA-S levels...Continue Reading

References

Sep 9, 2005·British Journal of Neurosurgery·S E BaldewegJ Ahlquist
Feb 9, 2007·European Journal of Endocrinology·Wolfgang SaegerStephan Petersenn
Oct 6, 2007·Endocrine Journal·Toru TatenoYukio Hirata
Jun 18, 2010·Reviews in Endocrine & Metabolic Disorders·Dima AbdelMannanBaha M Arafah
Sep 28, 2010·Journal of Neurosurgery·Gabriel ZadaEdward R Laws
Dec 8, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ribal Al-AridiBaha M Arafah
May 14, 2014·Nature Reviews. Endocrinology·Antonio Di IevaKalman Kovacs
Feb 3, 2015·Neurosurgical Focus·Vivek BansalBaha M Arafah
Feb 7, 2016·European Journal of Endocrinology·Nadine El-AsmarBaha M Arafah

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Citations

Jan 19, 2018·Pituitary·Anat Ben-Shlomo, Odelia Cooper
Mar 3, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Chung Thong Lim, Márta Korbonits
Jul 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Juliana DrummondMárta Korbonits
Jan 31, 2020·The Journal of Clinical Endocrinology and Metabolism·Baha M Arafah
Dec 16, 2017·The Journal of Clinical Endocrinology and Metabolism·Nadine El AsmarBaha M Arafah
Jan 13, 2021·Current Medical Imaging·Federico PontiAlessandro Marinelli
Jul 6, 2021·Frontiers in Endocrinology·Masaaki YamamotoHidenori Fukuoka

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