PMID: 14649345Dec 3, 2003Paper

Perioperative intravenous adenosine infusion to extend postoperative analgesia in brachial plexus block

European Journal of Anaesthesiology
A ApanH Basar


Adenosine infusions have been shown to reduce requirements of anaesthetics, to decrease the need for postoperative analgesics and to attenuate hyperaesthesia related to neuropathic pain. We decided to investigate the effects, beneficial or otherwise, of an adenosine infusion administered during surgery. A brachial plexus block was used to produce anaesthesia for the surgery. Sixty adults undergoing upper extremity surgery were included in the study. Brachial plexus block was performed via an axillary approach with lidocaine 1.25% and epinephrine 1/200 000 (40 mL). Patients were randomly assigned to two groups. During surgery, saline (control) or adenosine 80 microg kg min was infused intravenously in a double-blind fashion for 1 h. Visual analogue scores every 4 h, analgesic consumption, time to first spontaneous pain sensation, time to first rescue analgesic and adverse effects were noted during the first 24 h. Vital signs were stable in both groups throughout surgery. During the adenosine infusion, one patient fainted while another complained of palpitations and tightness of the chest; both patients were excluded from further analyses. The time to first sensation of pain was significantly longer in the adenosine group compare...Continue Reading


Jun 4, 1987·European Journal of Pharmacology·T DoiY Maki
Jan 1, 1989·Neuroscience·J Sawynok, M I Sweeney
Mar 21, 1989·European Journal of Pharmacology·K Herrick-DavisS J Ward
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·M HolmgrenT Hedner
Apr 1, 1997·Acta Anaesthesiologica Scandinavica·M SegerdahlA Sollevi
Aug 12, 2000·Acta Anaesthesiologica Scandinavica·K RaneM Segerdahl

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