Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety

Pain
Martin BaileyAndrew J Toner

Abstract

Chronic postsurgical pain (CPSP) occurs in 12% of surgical populations and is a high priority for perioperative research. Systemic lidocaine may modulate several of the pathophysiological processes linked to CPSP. This systematic review aims to identify and synthesize the evidence linking lidocaine infusions and CPSP. The authors conducted a systematic literature search of the major medical databases from inception until October 2017. Trials that randomized adults without baseline pain to perioperative lidocaine infusion or placebo were included if they reported on CPSP. The primary outcome was the presence of procedure-related pain at 3 months or longer after surgery. The secondary outcomes of pain intensity, adverse safety events, and local anesthetic toxicity were also assessed. Six trials from 4 countries (n = 420) were identified. Chronic postsurgical pain incidence was consistent with existing epidemiological data. Perioperative lidocaine infusions significantly reduced the primary outcome (odds ratio, 0.29; 95% confidence interval, 0.18-0.48), although the difference in intensity of CPSP assessed by the short-form McGill Pain Questionnaire (4 trials) was not statistically significant (weighted mean difference, -1.55; 95%...Continue Reading

Associated Clinical Trials

Sep 11, 2018·Xiangcai Ruan, MD, PhD, Vice-Director in Dept Anesth & Pain
Sep 17, 2018·Xiangcai Ruan, MD, PhD, Vice-Director in Dept Anesth & Pain

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Citations

Feb 16, 2019·Pain·Martin Bailey
Jan 21, 2021·Der Schmerz·Esther Pogatzki-Zahn
Oct 11, 2019·Drugs & Aging·Rachel WaldingerMarina Gitman
May 28, 2019·Deutsches Ärzteblatt International·Dominik GeilWinfried Meissner
Oct 24, 2020·Paediatric Drugs·Christopher S LeeVidya Chidambaran
Dec 8, 2020·Current Anesthesiology Reports·Maria F RamirezJuan P Cata
Jan 16, 2020·Anaesthesia and Intensive Care·Martin A BaileyTomas B Corcoran
Aug 15, 2020·British Journal of Anaesthesia·Dylan T Finnerty, Donal J Buggy
May 13, 2021·JBJS Case Connector·Jordan ArakawaDarin Friess
Aug 28, 2021·Medicina·Entaz Bahar, Hyonok Yoon

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