Perioperative myocardial injury and hemostasis in patients undergoing endovascular aneurysm repair for asymptomatic infrarenal abdominal aortic aneurysm

Vascular and Endovascular Surgery
Robert S M DaviesDonald J Adam

Abstract

(1) To report the incidence of myocardial injury in patients undergoing endovascular aortic aneurysm repair (EVAR) through the routine measurement of perioperative cardiac troponin-T (cTnT) and (2) to investigate and correlate changes in perioperative cTnT levels with any concomitant hemostatic derangement. Prospective study of 30 patients undergoing elective EVAR for infrarenal abdominal aortic aneurysm. Cardiac TnT was assayed at 24 hours postoperatively. Plasma thrombin antithrombin III complex (TAT), plasminogen activator inhibitor 1 (PAI-1), tissue plasminogen activator (t-PA) activity, and soluble P-selectin (sP-selectin) were assayed preoperatively and at 24 hours postoperatively. Five (17%) patients demonstrated elevated cTnT levels at 24 hours; 3 patients had no clinical evidence of myocardial injury. There was a positive correlation between cTnT and TAT levels at 24 hours post-EVAR (r = .38, P = .039, Kendall-tau B = 0.26). Endovascular aortic aneurysm repair is associated with a significant risk of perioperative myocardial injury that is underdetected clinically and associated with a procoagulopathic state.

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Citations

Aug 10, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Roy K GreenbergKenneth Ouriel
Feb 13, 2007·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Roel HoboUNKNOWN EUROSTAR Collaborators
Feb 13, 2007·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Volker RuppertUNKNOWN EUROSTAR Collaborators
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Jul 5, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Armando C LobatoEdward B Diethrich
Sep 12, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Venkatesh G RamaiahEdward B Diethrich
Sep 12, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Thomas PfammatterUlrich Blum
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