Perioperative neutrophil:lymphocyte ratio and postoperative NSAID use as predictors of survival after lung cancer surgery: a retrospective study

Cancer Medicine
Jae Eun ChoiJuan P Cata

Abstract

The association between neutrophil:lymphocyte ratio (NLR) and poor long-term outcomes in patients with non-small-cell lung cancer (NSCLC) has been demonstrated in numerous studies. The benefit of perioperative administration of anti-inflammatory drugs on these outcomes has not been well established. Our aim in this retrospective study was to investigate the effects of postoperative nonsteroidal anti-inflammatory drug (NSAID) administration and NLR on tumor recurrence and survival in patients' undergoing surgical resection for NSCLC. This retrospective study included perioperative data from 1139 patients who underwent surgical resection for stages I-III NSCLC. Perioperative data such as baseline characteristics, adjuvant or neoadjuvant therapy, pre- and postoperative NLR, and NSAID use (ketorolac, ibuprofen, celecoxib, or in combination) were included. We evaluated the association between preoperative NLR and NSAID use on recurrence-free (RFS) and overall survival (OS). In all, 563 patients received an NSAID as a part of their postoperative management. The majority of patients received ketorolac (n = 374, 67.16%). Ketorolac administration was marginally associated with better OS (P = 0.05) but not with RFS (P = 0.38). Multivaria...Continue Reading

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Citations

Sep 4, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·W-G LanL-B Ma
Dec 29, 2017·Nature Reviews. Clinical Oncology·Jonathan G HillerErica K Sloan
Jul 28, 2019·Cancers·Laurie G HudsonAngela Wandinger-Ness
Sep 14, 2016·International Anesthesiology Clinics·Itay RiconShamgar Ben-Eliyahu
Sep 15, 2020·Cancer Management and Research·Xiaoqing FanRuiting Wang
Jun 28, 2018·Journal of Cardiothoracic Surgery·Shinjiro MizuguchiNoritoshi Nishiyama
Jun 9, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Luke V SelbyDavid J Douin
Oct 13, 2021·Pain Management·Maria F RamirezJuan P Cata

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Methods Mentioned

BETA
surgical resection

Software Mentioned

Plus
REDCap ( Research Electronic Data Capture )
SAS

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