Perioperative outcomes of interrupted anticoagulation in patients with non-valvular atrial fibrillation undergoing non-cardiac surgery

Yeungnam University Journal of Medicine
Bo Eun ParkShung Chull Chae

Abstract

This study aimed to investigate the incidences of and risk factors for perioperative events following anticoagulant discontinuation in patients with non-valvular atrial fibrillation (NVAF) undergoing non-cardiac surgery. A total of 216 consecutive patients who underwent cardiac consultation for suspending perioperative anticoagulants were enrolled. A perioperative event was defined as a composite of thromboembolism and major bleeding. The mean anticoagulant discontinuation duration was 5.7 (±4.2) days and was significantly longer in the warfarin group (p<0.001). Four perioperative thromboembolic (1.85%; three strokes and one systemic embolization) and three major bleeding events (1.39%) were observed. The high CHA2DS2-VASc and HAS-BLED scores and a prolonged preoperative anticoagulant discontinuation duration (4.4±2.1 vs. 2.9±1.8 days; p=0.028) were associated with perioperative events, whereas the anticoagulant type (non-vitamin K antagonist oral anticoagulants or warfarin) was not. The best cut-off levels of the HAS-BLED and CHA2DS2-VASc scores were 3.5 and 2.5, respectively, and the preoperative anticoagulant discontinuation duration for predicting perioperative events was 2.5 days. Significant differences in the perioperati...Continue Reading

References

May 22, 1997·The New England Journal of Medicine·C Kearon, J Hirsh
Feb 24, 1998·Archives of Internal Medicine·P A WolfR B D'Agostino
Sep 12, 2003·The New England Journal of Medicine·Elaine M HylekDaniel E Singer
Mar 11, 2006·Stroke; a Journal of Cerebral Circulation·Elena Birman-DeychBrian F Gage
Oct 20, 2007·Lancet Neurology·Gregory Y H Lip, Hoong Sern Lim
Jan 16, 2008·Archives of Internal Medicine·David A GarciaElaine M Hylek
Feb 19, 2008·Thrombosis and Haemostasis·Michael HughesUNKNOWN Guideline Development Group, National Clinical Guideline for Management of Atrial Fibrillation in Primary and Secondary Care
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Nov 5, 2010·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN Randomized Evaluation of Long-Term Anticoagulation Therapy Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Oct 10, 2013·Polskie Archiwum Medycyny Wewnętrznej·Jelena KornejGregory Y H Lip
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Aug 30, 2016·The American Journal of Medicine·Jerrold H Levy
Feb 9, 2017·Circulation·Amish N RavalUNKNOWN American Heart Association Clinical Pharmacology Subcommittee of the Acute Cardiac Care and General Cardiology Committee of
Mar 24, 2017·Thrombosis and Haemostasis·José Miguel Rivera-CaravacaFrancisco Marín

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Innovative Surgical Sciences
Johanna WagnerA Wiegering
Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
J F LockA Wiegering
The Medical Clinics of North America
James B Froehlich, Lee A Fleisher
Anesthesiology Clinics
James B Froehlich, Lee A Fleisher
© 2021 Meta ULC. All rights reserved