Perioperative PET/CT lymphoscintigraphy and fluorescent real-time imaging for sentinel lymph node mapping in early staged colon cancer

European Journal of Nuclear Medicine and Molecular Imaging
Marjolein AnkersmitW J H J Meijerink

Abstract

Using current optical imaging techniques and gamma imaging modalities, perioperative sentinel lymph node (SLN) identification in colon cancer can be difficult when the SLN is located near the primary tumour or beneath a thick layer of (fat) tissue. Sentinel lymph node mapping using PET/CT lymphoscintigraphy combined with real-time visualization of the SLN using near-infrared imaging has shown promising results in several types of cancer and may facilitate the successful identification of the number and location of the SLN in early colon cancer. Clinical feasibility of PET/CT lymphoscintigraphy using preoperative endoscopically injected [89Zr]Zr-Nanocoll and intraoperative injection of the near-infrared (NIR) tracer Indocyanine Green (ICG) was evaluated in ten early colon cancer patients. Three preoperative PET/CT scans and an additional ex vivo scan of the specimen were performed after submucosal injection of [89Zr]Zr-Nanocoll. All SLNs and other lymph nodes underwent extensive pathological examination for metastases. A histopathological proven lymph node visible at preoperative PET/CT and identified at PET/CT of the specimen was defined as SLN. A total of 27 SLNs were harvested in seven out of eight patients with successful in...Continue Reading

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Citations

Jun 21, 2020·International Journal of Molecular Sciences·Joon-Kee YoonSu-Jin Lee
May 9, 2021·Cellular and Molecular Life Sciences : CMLS·Xingzhou PengZhihong Zhang
Jun 30, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Thomas WendlerMatthias N van Oosterom

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Methods Mentioned

BETA
biopsies
biopsy

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NCT02850783

Software Mentioned

SPSS
Vinci

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