Perioperative Red Blood Cell Transfusion: What We Do Not Know

Chinese Medical Journal
Chong Lei, Li-Ze Xiong

Abstract

Blood transfusion saves lives but may also increase the risk of injury. The objective of this review was to evaluate the possible adverse effects related to transfusion of red blood cell (RBC) concentrates stored for prolonged periods. The data used in this review were mainly from PubMed articles published in English up to February 2015. Clinical and basic research articles were selected according to their relevance to this topic. The ex vivo changes to RBC that occur during storage are collectively called storage lesion. It is still inconclusive if transfusion of RBC with storage lesion has clinical relevance. Multiple ongoing prospective randomized controlled trials are aimed to clarify this clinical issue. It was observed that the adverse events related to stored RBC transfusion were prominent in certain patient populations, including trauma, critical care, pediatric, and cardiac surgery patients, which leads to the investigation of underlying mechanisms. It is demonstrated that free hemoglobin toxicity, decreasing of nitric oxide bioavailability, and free iron-induced increasing of inflammation may play an important role in this process. It is still unclear whether transfusion of older RBC has adverse effects, and if so, wh...Continue Reading

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Clinical Trials Mentioned

ISRCTN44878718
ISRCTN08118744
NCT00326924
NCT00991341
NCT00458783
NCT01638416

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