Perioperative Research into Memory (PRiMe): Cognitive impairment following a severe burn injury and critical care admission, part 1

Burns : Journal of the International Society for Burn Injuries
Edward J R WatsonMarcela P Vizcaychipi

Abstract

An investigation into long-term cognitive impairment and Quality of Life (QoL) after severe burns. A proof of principle, cohort design, prospective, observational clinical study. Patients with severe burns (>15% TBSA) admitted to Burns ICU for invasive ventilation were recruited for psychocognitive assessment with a convenience sample of age and sex-matched controls. Participants completed psychological and QoL questionnaires, the Cogstate® electronic battery, Hopkins Verbal Learning, Verbal Fluency and Trail making tasks. 15 patients (11M, 4F; 41±14 years; TBSA 38.4%±18.5) and comparators (11M, 4F; 40±13 years) were recruited. Burns patients reported worse QoL (Neuro-QoL Short Form v2, patient 30.1±8.2, control 38.7±3.2, p=0.0004) and cognitive function (patient composite z-score 0.01, IQR -0.11 to 0.33, control 0.13, IQR 0.47-0.73, p=0.02). Compared to estimated premorbid FSIQ, patients dropped an equivalent of 8 IQ points (p=0.002). Cognitive function negatively correlated with burn severity (rBaux score, p=0.04). QoL strongly correlated with depressive symptoms (Rho=-0.67, p=0.009) but not cognitive function. Severe burns injuries are associated with a significant, global, cognitive deficit. Patients also report worse QoL, ...Continue Reading

Citations

Sep 11, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Stephanie R CiminoSander L Hitzig
Dec 5, 2019·Frontiers in Bioengineering and Biotechnology·Xiuni ZhangAiling Hu
Oct 23, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Elise Boersma-van DamNancy E E Van Loey

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